Table 2

The MTHFR and TYMS genotype distributions, relative fitnesses and deviations from HWE of the genotypes in the 5 populations from Norfolk and Cumbria

MTHFR

CC

CT

TT

Relative fitness

CC vs CT

Relative fitness

TT vs CT

Deviation from HWE


Cohort 1

Observed

486.0

564.0

128.0

0.92

0.85

0.063

Expected

500.7

534.6

142.7

Cohort 2

Observed

206.0

191.0

41.0

0.98

0.95

0.824

Expected

207.5

187.9

42.5

Cohort 3

Observed

179.0

178.0

52.0

1.06

1.11

0.445

Expected

175.6

184.8

48.6

Cohort 4

Observed

166.0

202.0

30.0

0.81

0.61

0.003

Expected

179.1

175.8

43.1

Cohort 5

Observed

185.0

214.0

76.0

1.08

1.13

0.287

Expected

179.5

225.0

70.5


TYMS

3_3

2_3

2_2

Relative fitness

3_3 vs 3_2

Relative fitness

2_2 vs 3_2

Deviation from HWE


Cohort 1

Observed

350.0

541.0

287.0

1.16

1.18

0.007

Expected

326.8

587.3

263.8

Cohort 2

Observed

126.0

216.0

96.0

1.02

1.01

0.848

Expected

125.0

218.0

95.0

Cohort 3

Observed

129.0

180.0

100.0

1.24

1.28

0.022

Expected

117.3

203.5

88.3

Cohort 4

Observed

124.0

184.0

90.0

1.14

1.16

0.189

Expected

117.2

197.6

83.2

Cohort 5

Observed

146.0

240.0

89.0

0.96

0.94

0.641

Expected

149.0

234.1

92.0


Observed and expected genotype frequencies and deviations from HWE were calculated from the prevalence data for the MTHFR 677 and TYMS 5'UTR loci in 2898 samples that were simultaneously genotyped at both loci

Jennings et al. BMC Medical Genetics 2010 11:18   doi:10.1186/1471-2350-11-18

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