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Open Access Highly Accessed Research article

Genetic selection? A study of individual variation in the enzymes of folate metabolism

Barbara A Jennings*, Gavin A Willis, Jane Skinner and Caroline L Relton

BMC Medical Genetics 2010, 11:18  doi:10.1186/1471-2350-11-18

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Bibliography update

Armando Reyes-Engel   (2010-03-22 16:33)  University of Malaga, Spain email

We believe this is a very interesting article on a topic of research in which we are involved especially. As it is mentioned in the history of this publication there are very few articles published about this issue (one review and 5 original papers), and should not pose any problem to update the bibliography in this area. I am sending this letter to remark that our team published the first article, about this subject in The Lancet in 1998 whose title must not be overlooked, in any search, since it includes the words Genetic Selection and folate, and a second article in which the design is similar to this one because we refer to distribute the population into four cohorts and that also includes the term of genetic selection with the MTHFR gene polymorphism in the title. No other interest than scientific recognition, without which we would lack professional motivation and economic loss, we send this comment.
Bibliography about Human Genetic Selection and Folate

Genetic selection and folate intake during pregnancy.
Muñoz-Moran E, Dieguez-Lucena JL, Fernandez-Arcas N, Peran-Mesa S, Reyes-Engel A.
Lancet. 1998 Oct 3;352(9134):1120-1. No abstract available. PMID: 9798595 [PubMed - indexed for MEDLINE]Related articles

Implications on human fertility of the 677C-->T and 1298A-->C polymorphisms of the MTHFR gene: consequences of a possible genetic selection.
Reyes-Engel A, Muñoz E, Gaitan MJ, Fabre E, Gallo M, Dieguez JL, Ruiz M, Morell M.
Mol Hum Reprod. 2002 Oct;8(10):952-7.PMID: 12356947 [PubMed - indexed for MEDLINE]Related articlesFree article

Folic acid - vitamin and panacea or genetic time bomb?
Lucock M, Yates Z.
Nat Rev Genet. 2005 Mar;6(3):235-40. Review.PMID: 15738964 [PubMed - indexed for MEDLINE]Related articles

Preliminary evidence for genetic selection of 677T-MTHFR by natural annual cycle of folate abundance.
Lucock M, Yates Z, Ng X, Veysey M, Blades B, Travers C, Lewis P, Sturm J, Roach P.
J Nutrigenet Nutrigenomics. 2008;1(1-2):24-9. Epub 2007 Oct 16.PMID: 19918112 [PubMed - indexed for MEDLINE]Related articles

Folic acid use in pregnancy and embryo selection.
Haggarty P, Campbell DM, Duthie S, Andrews K, Hoad G, Piyathilake C, Fraser I, McNeill G.
BJOG. 2008 Jun;115(7):851-6.PMID: 18485163 [PubMed - indexed for MEDLINE]Related articles

Human genetic selection on the MTHFR 677C>T polymorphism.
Mayor-Olea A, Callejón G, Palomares AR, Jiménez AJ, Gaitán MJ, Rodríguez A, Ruiz M, Reyes-Engel A.
BMC Med Genet. 2008 Nov 28;9:104.PMID: 19040733 [PubMed - indexed for MEDLINE]Related articlesFree article

Competing interests

no competing interest


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