Table 5

Association analysis for the relationship between validated SNPs in the explored candidate genes and quantitative variables of hyperandrogenemia in PCOS with genetic effect sizes estimates derived for a log-additive genetic model (MC4R rs2229616 dominant genetic model) for the minor allele (see also Table 1).

testosterone [nmol/l]

FAI

bioavailable testosterone [ng/ml]

gene (SNP) minor allele

β

95% CI

p

β

95% CI

p

β

95% CI

p

FTO (rs9939609) A

-0.01

(-0.41;0.39)

0.95

5.25

(-7.11;17.60)

0.41

0.03

(-0.09;0.15)

0.64

INSIG2 (rs7566605) C

-0.16

(-0.58;0.26)

0.46

-6.33

(-19.36;6.71)

0.34

-0.07

(-0.20;0.05)

0.25

TCF7L2 (rs7903146) T

0.20

(-0.25;0.64)

0.38

7.93

(-5.90;21.77)

0.26

0.04

(-0.09;0.18)

0.50

MC4R (rs2229616) T

-0.28

(-1.88;1.32)

0.73

-12.18

(-60.54;36.17)

0.62

-0.08

(-0.54;0.38)

0.73

MC4R (rs17782313) C

-0.25

(-0.70;0.19)

0.27

-3.47

(-17.33;10.40)

0.62

-0.05

(-0.18;0.08)

0.46

MC4R (rs12970134) A

0.15

(-0.29;0.58)

0.51

7.26

(-5.97;20.49)

0.28

0.07

(-0.06;0.19)

0.30

SNP = single nucleotide polymorphism; FAI = free androgen index

Tan et al. BMC Medical Genetics 2010 11:12   doi:10.1186/1471-2350-11-12