Open Access Research article

Search for copy number variants in chromosomes 15q11-q13 and 22q11.2 in obsessive compulsive disorder

Richard Delorme12, Daniel Moreno-De-Luca345, Aurélie Gennetier345, Wolfgang Maier6, Pauline Chaste12, Rainald Mössner6, Hans Jörgen Grabe7, Stephan Ruhrmann8, Peter Falkai9, Marie-Christine Mouren2, Marion Leboyer11011, Michael Wagner6 and Catalina Betancur345*

Author Affiliations

1 INSERM, U955, Institut Mondor de Recherche Biomédicale, Psychiatric Genetics, Créteil, France

2 AP-HP, Hôpital Robert Debré, Department of Child and Adolescent Psychiatry, Paris, France

3 INSERM, U952, Paris, France

4 CNRS, UMR 7224, Paris, France

5 UPMC Univ Paris 06, Paris, France

6 Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany

7 Department of Psychiatry and Psychotherapy, University of Greifswald, Stralsund, Germany

8 Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany

9 Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Germany

10 AP-HP, Henri Mondor-Albert Chenevier Hospital, Department of Psychiatry, Créteil, France

11 Université Paris 12, Faculty of Medicine, Créteil, France

For all author emails, please log on.

BMC Medical Genetics 2010, 11:100  doi:10.1186/1471-2350-11-100

Published: 21 June 2010

Abstract

Background

Obsessive-compulsive disorder (OCD) is a clinically and etiologically heterogeneous syndrome. The high frequency of obsessive-compulsive symptoms reported in subjects with the 22q11.2 deletion syndrome (DiGeorge/velocardiofacial syndrome) or Prader-Willi syndrome (15q11-13 deletion of the paternally derived chromosome), suggests that gene dosage effects in these chromosomal regions could increase risk for OCD. Therefore, the aim of this study was to search for microrearrangements in these two regions in OCD patients.

Methods

We screened the 15q11-13 and 22q11.2 chromosomal regions for genomic imbalances in 236 patients with OCD using multiplex ligation-dependent probe amplification (MLPA).

Results

No deletions or duplications involving 15q11-13 or 22q11.2 were identified in our patients.

Conclusions

Our results suggest that deletions/duplications of chromosomes 15q11-13 and 22q11.2 are rare in OCD. Despite the negative findings in these two regions, the search for copy number variants in OCD using genome-wide array-based methods is a highly promising approach to identify genes of etiologic importance in the development of OCD.