Table 4

Associations of NR4A3 SNPs rs1526267, rs12686676 and rs10819699 with metabolic data and insulin secretion indices (METSIM cohort, N = 5265)

SNP

rs1526267

Genotype

GG

GA

AA

p₁

p₂

p₃

N

2311

2317

637

-

-

-

Age (y)

58 ± 6

58 ± 7

58 ± 6

0.3

-

-

BMI (kg/m²)

26.8 ± 3.7

26.8 ± 3.8

26.7 ± 3.7

0.5

-

-

Insulin sensitivity (HOMA), OGTT (AU)

2.10 ± 1.55

2.11 ± 1.54

1.95 ± 1.32

0.14

0.12

-

AUC_Ins30-to-AUC_Gluc30 ratio, OGTT (·10^-9)

34.7 ± 24

35.9 ± 25

34.0 ± 24

0.0381

0.08

0.12

Insulin, 30 min OGTT (pM)

445 ± 320

464 ± 340

437 ± 314

0.040

0.10

0.10

SNP

rs12686676

Genotype

GG

GA

AA

p₁

p₂

P₃

N

1127

2520

1585

-

-

-

Age (y)

58 ± 6

59 ± 7

58 ± 6

0.3

-

-

BMI (kg/m²)

26.8 ± 3.6

26.9 ± 3.9

26.7 ± 3.7

0.14

-

-

Insulin sensitivity (HOMA), OGTT (AU)

2.02 ± 1.40

2.12 ± 1.58

2.10 ± 1.54

0.3

0.6

-

AUC_Ins30-to-AUC_Gluc30 ratio, OGTT (·10^-9)

34.3 ± 23

36.2 ± 25

34.4 ± 23

0.021

0.09

0.029

Insulin, 30 min OGTT (pM)

441 ± 320

466 ± 345

442 ± 314

0.025

0.11

0.038

SNP

rs10819699

Genotype

GG

GA

AA

p₁

p₂

p₃

N

1830

2480

913

-

-

-

Age (y)

58 ± 6

58 ± 7

58 ± 6

0.6

-

-

BMI (kg/m²)

26.8 ± 3.7

26.9 ± 3.8

26.8 ± 3.8

0.5

-

-

Insulin sensitivity (HOMA), OGTT (AU)

2.11 ± 1.61

2.09 ± 1.47

2.02 ± 1.47

0.3

0.3

-

AUC_Ins30-to-AUC_Gluc30 ratio, OGTT (·10^-9)

34.9 ± 24

35.6 ± 24

35.1 ± 25

0.2

0.5

0.4

Insulin, 30 min OGTT (pM)

447 ± 325

459 ± 332

451 ± 336

0.2

0.4

0.3

Data are given as means ± SD. For statistical analysis, data were log-transformed. p₁ – non-adjusted additive model; p₂ – additive model with adjustements to BMI and age; p₃ – AUC_Ins30-to-AUC_Gluc30 ratio and plasma insulin at 30 min OGTT with adjustements for age, BMI and insulin sensitivity; AUC – area under the curve; OGTT – oral glucose tolerance test; SNP – single nucleotide polymorphism, Gluc – Glucose, Ins – Insulin.

Weyrich et al. BMC Medical Genetics 2009 10:77   doi:10.1186/1471-2350-10-77