Research article
Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced β-cell function in non-diabetic subjects
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* Corresponding author: Harald Staiger harald.staiger@med.uni-tuebingen.de
- † Equal contributors
1 Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany
2 Department of Medicine, Kuopio University Hospital, Kuopio, Finland
BMC Medical Genetics 2009, 10:77 doi:10.1186/1471-2350-10-77
Published: 14 August 2009Additional files
Additional file 1:
Associations of NR4A3 SNPs rs7047636 and rs2416879 with anthropometric and metabolic data (TÜF/TULIP cohort, N = 1495). Data are given as means ± SD. For statistical analysis, data were log-transformed. p1 – non-adjusted additive model; p2 – adjusted additive model: age was adjusted for gender; BMI and body fat were adjusted for gender and age; glucose (Gluc) levels as well as insulin sensitivity (HOMA model, clamp) and insulin (Ins) secretion (AUCC-peptide-to-AUCGluc ratio, AUCIns30-to-AUCGluc30 ratio, plasma insulin at 30 min OGTT) were adjusted for gender, age, and BMI; p3 – Ins secretion parameters with adjustment for age, BMI, gender and insulin sensitivity. *clamped subgroup (N = 506). AUC – area under the curve; BMI – body mass index; OGTT – oral glucose tolerance test; SNP – single nucleotide polymorphism.
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Additional file 2:
Logistic regression analysis for differences of NR4A3 SNP's minor allele prevalences in individuals with normal glucose tolerance (NGT) and overt diabetes mellitus (DM) in the METSIM Study. The [95%] confidence interval of the data provided is indicated for all different statistical models (additive, dominant, recessive) for all investigated SNPs.
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Additional file 3:
Distribution of NR4A3 SNP minor allele frequencies according to glucose tolerance status in the TÜF/TULIP (N = 1495) and the METSIM (N = 6147) cohort. Minor allele frequencies for each investigated NR4A3 SNP are presented for study participants (TUEF-TULIP/METSIM trial) with normal glucose tolerance (NGT), impaired fasting glucose and/or impaired glucose tolerance (IFG/IGT) and with manifest diabetes (METSIM participants only). p1 – NGT vs. IFG/IGT in TUEF-TULIP/METSIM(χ2-test); p2 – NGTvs.IFG/IGTvs.DIABETESinMETSIM(χ2-test). SNPs screened in TUEF/TULIP only and not replicated in METSIM are marked with an asterisk.
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