Table 5 |
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|
Postnatal characteristics at 6, 12, and 24 months according to TCF7L2 rs7903146 genotype. |
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|
Generation R |
CC (n = 1375) |
CT (n = 1063) |
TT (n = 237) |
p-value# |
|
|
|
|||||
|
6 months |
Head circumference (SDS) |
-0.02 (0.93) |
-0.03 (0.89) |
-0.06 (0.91) |
0.83 |
|
n = 2675 |
Height (SDS) |
0.03 (0.91) |
0.03 (0.90) |
0.07 (0.93) |
0.81 |
|
Weight (SDS) |
0.41 (0.96) |
0.44 (0.95) |
0.54 (0.99) |
0.14 |
|
|
12 months |
Head circumference (SDS) |
0.00 (0.89) |
-0.04 (0.94) |
-0.03 (1.12) |
0.54 |
|
n = 2559 |
Height (SDS) |
-0.01 (0.90) |
-0.05 (0.90) |
-0.01 (0.90) |
0.70 |
|
Weight (SDS) |
0.18 (0.98) |
0.18 (0.99) |
0.24 (1.00) |
0.63 |
|
|
24 months |
Height (SDS) |
-0.19 (0.93) |
-0.21 (0.89) |
-0.18 (0.87) |
0.82 |
|
n = 2445 |
Weight (SDS) |
-0.11 (0.99) |
-0.13 (1.00) |
-0.09 (0.96) |
0.87 |
|
|
|||||
|
SGA cohort |
CC (n = 143) |
CT (n = 107) |
TT (n = 22) |
||
|
|
|||||
|
6 months |
Head circumference (SDS) |
-1.38 (0.92) |
-1.36 (0.90) |
-1.74 (1.04) |
0.41 |
|
n = 272 |
Height (SDS) |
-2.39 (1.37) |
-2.43 (1.26) |
-2.51 (1.55) |
0.93 |
|
Weight (SDS) |
-2.18 (1.40) |
-2.22 (1.26) |
-2.37 (2.05) |
0.86 |
|
|
12 months |
Head circumference (SDS) |
-1.21 (0.83) |
-1.24 (0.88) |
-1.72 (1.06) |
0.16 |
|
n = 268 |
Height (SDS) |
-2.25 (1.25) |
-2.30 (1.06) |
-2.30 (1.47) |
0.94 |
|
Weight (SDS) |
-2.14 (1.41) |
-2.25 (1.15) |
-2.17 (1.89) |
0.82 |
|
|
24 months |
Head circumference (SDS) |
-1.10 (0.82) |
-1.13 (0.87) |
-1.60 (1.06) |
0.20 |
|
n = 244 |
Height (SDS) |
-2.39 (1.24) |
-2.47 (1.05) |
-2.94 (1.04) |
0.20 |
|
Weight (SDS) |
-2.19 (1.33) |
-2.31 (1.21) |
-3.06 (1.65) |
0.04 |
|
|
|
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|
Values expressed as mean (SD). SDS = standard deviation score for age and gender. # p-values for additive models. Differences were tested using linear regression. |
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|
Mook-Kanamori et al. BMC Medical Genetics 2009 10:67 doi:10.1186/1471-2350-10-67 |
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