Figure 4.

Cross-species comparison of the protein sequences of (A) two TRPM6 segments encompassing the two non-synonymous SNPs, V1393I and K1584E (21 amino acids each, centered at the non-synonymous SNP) in human (GenBank accession number Q9BX84), chimpanzee (GenBank accession number XP_528327), and mouse (GenBank accession number Q8CIR4); and (B) a TRPM7 segment encompassing the non-synonymous SNP, T1482I (21 amino acids, centered at the non-synonymous SNP) in human (GenBank accession number Q96QT4), Sheep (GenBank accession number ABP35923), mouse (GenBank accession number Q923J1), and zebra fish (GenBank accession number NP_001025232). The asterisks denote amino acid residues conserved across all the species that were compared.