Table 3 |
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|
Summary of linkage analyses |
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|
Chromosome1/Position2 |
Model Independent Linkage Analysis LOD score |
Ordered Subset Analysis Gene × smoking LOD score (p-value3) |
Parametric Linkage Analysis LOD score |
|||
|
|
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|
Narrower4 |
Broader5 |
Narrower4 |
Broader5 |
Narrower4 |
Broader5 |
|
|
|
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|
4q32.3/160–162 cM |
0.5 |
1.3 |
NS6 |
NS |
1.6 |
2.6 |
|
7p14.1/60–63 cM |
0.7 |
0.6 |
4.1 (0.001) |
3.2 (0.01) |
0.4 |
0.7 |
|
7q22.3/116–118 cM |
1.5 |
1.3 |
NS |
NS |
1.6 |
1.3 |
|
12p12.3/35–50 cM |
1.4 |
1.4 |
NS |
NS |
2.4 |
3.1 |
|
|
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|
1 Cytogenetic position of the maximum LOD score 2 Location of the maximum LOD score on the deCode map 3 Permutation testing was performed to obtain p-values associated with the increase in LOD score observed when modeling gene × smoking interaction when compared with modeling for genetic effects only. 4 Narrower disease model (n = 290 families) 5 Broader disease model (n = 333 families) 6 Not significant |
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|
Foroud et al. BMC Medical Genetics 2009 10:3 doi:10.1186/1471-2350-10-3 |
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