Table 2 |
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|
Results for (A) weight-for-height z-score and (B) reproductive success§ for 16 SNPs in FTO gene |
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|
(A) weight-for-height zscore1 |
(B) Reproductive success§2 |
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|
SNP |
base change |
MAF [%] |
coef |
CI95% |
p |
% diff in birth rate |
CI95% |
p |
|
|
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|
rs6499642 |
C/T |
32.07 |
0.0373 |
(-0.0307, 0.1052) |
0.2725 |
4.7% |
(-1.0%, 10.9%) |
0.1017 |
|
rs6499643 |
C/T |
43.07 |
0.0561 |
(-0.0073, 0.1194) |
0.0767 |
0.1% |
(-5.0%, 5.5%) |
0.9665 |
|
rs7206790 |
C/G |
39.68 |
-0.0313 |
(-0.0950, 0.0324) |
0.3262 |
-4.0% |
(-9.0%, 1.4%) |
0.1354 |
|
rs9940646 |
C/G |
41.26 |
0.0145 |
(-0.0497, 0.0788) |
0.6511 |
-0.7% |
(-5.6%, 4.5%) |
0.7842 |
|
rs12447107 |
C/G |
31.31 |
0.0152 |
(-0.0526, 0.0831) |
0.6534 |
-1.9% |
(-7.0%, 3.5%) |
0.4801 |
|
rs17817288 |
A/G |
37.91 |
-0.0016 |
(-0.0678, 0.0646) |
0.9612 |
4.3% |
(-0.7%, 9.5%) |
0.0845 |
|
rs16945088 |
A/G |
40.91 |
0.0281 |
(-0.0365, 0.0927) |
0.3846 |
5.1% |
(0.2%, 10.1%) |
0.0356 |
|
rs17817449 |
G/T |
34.50 |
-0.0039 |
(-0.0700, 0.0621) |
0.9052 |
-0.9% |
(-5.6%, 4.0%) |
0.7046 |
|
rs8063946 |
C/T |
41.93 |
0.0127 |
(-0.0518, 0.0772) |
0.6932 |
3.0% |
(-1.7%, 7.9%) |
0.2068 |
|
rs3751812 |
G/T |
4.39 |
0.0164 |
(-0.1376, 0.1703) |
0.8317 |
7.2% |
(-2.7%, 18.1%) |
0.1535 |
|
rs3751813 |
G/T |
44.43 |
-0.0243 |
(-0.0883, 0.0397) |
0.4471 |
4.2% |
(-0.8%, 9.4%) |
0.0929 |
|
rs9939609 |
A/T |
35.54 |
0.0019 |
(-0.0614, 0.0653) |
0.9512 |
-3.3% |
(-7.7%, 1.3%) |
0.1510 |
|
rs9931494 |
C/G |
12.42 |
0.0479 |
(-0.0467, 0.1425) |
0.3117 |
-1.5% |
(-7.7%, 5.2%) |
0.6475 |
|
rs7190492 |
A/G |
23.07 |
-0.0397 |
(-0.1136, 0.0342) |
0.2828 |
-1.9% |
(-7.7%, 4.4%) |
0.5421 |
|
rs7204609 |
C/T |
46.76 |
-0.0168 |
(-0.0819, 0.0482) |
0.6044 |
-3.1% |
(-7.6%, 1.6%) |
0.1787 |
|
rs9935403 |
G/A |
15.00 |
0.0644 |
(-0.0194, 0.1482) |
0.1244 |
-0.8% |
(-7.2%, 6.0%) |
0.8003 |
|
|
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|
Key: SNP single nucleotide polymorphism; MAF minor allele frequency §as number of babies born (interpreted taking account of the mother's age and duration of observation) 1 Sample size ranged between 2127 and 2164 and the number of family groups between 954 and 966 depending on SNP. Family group sizes ranged between 1 and 8. 2 Sample size ranged between 657 and 672 and number of family groups between 484 and 495 depending on SNP. Family group sizes ranged between 1 and 5. Total exposure ranged between 420 and 428 "reproductive lifetimes" and the number of births between 2985 and 3062. The tabulated p-values are not corrected for multiple testing. The Bonferroni correction to account for testing 16 SNPs and achieve significance at the 5% level requires that the uncorrected p-value should be < 0.0033. In no case is this cut-off reached. |
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|
Hennig et al. BMC Medical Genetics 2009 10:21 doi:10.1186/1471-2350-10-21 |
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