Research article
FTO gene variation and measures of body mass in an African population
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* Corresponding author: Branwen J Hennig branwen.hennig@lshtm.ac.uk
- † Equal contributors
1 MRC International Nutrition Group, NPHIRU, EPH, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK
2 Medical Genetics Unit, Ospedale S. Pietro FBF, 00189 Rome, Italy
3 MRC Keneba, Medical Research Council Laboratories, Fajara, PO Box 273, Banjul, Gambia
4 Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter EX1 2LU, UK
5 Diabetes Genetics, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter EX1 2LU, UK
BMC Medical Genetics 2009, 10:21 doi:10.1186/1471-2350-10-21
Published: 5 March 2009Additional files
Additional file 1:
Tables S1–S3. Table S1 gives a sample size breakdown by outcome measure and reason for inclusion; in Table S2 we present additional results for 16 FTO SNPs on (A) body mass as BWT (mothers' and babies' genotypes), early weight gain and BMI and (B) indices of fertility as age at first delivery and seasonality and Table S3 shows the distribution of BMI in Gambian study population.
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Additional file 2:
Figure S2: Location of polymorphisms genotyped across FTO locus and Linkage disequilibrium structure in different populations. Heat maps based on Gambian and HapMap YRI comparative data of the LD structure of a section of the FTO gene is shown in Figure S2.
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Additional file 3:
Methods S1: Detailed statistical methods of measures of body mass and reproductive success. The data provided represents the construction of weight-for-height z-score, analysis of female fertility (including age at first delivery, and seasonality of birth). Figure S1 shows the empirical distribution functions for births before and after 1980 and the fitted distribution function based on the pooled data.
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