Table 2 |
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|
Case-control studies of overweight, obesity and morbid obesity in the combined study sample |
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|
CTNNBL1 rs6013029 |
n (men/women) |
Genotype distribution n GG/GT/TT (%) |
MAF (95% CI) |
padd |
pdom |
ORadd (95% CI) |
|
|
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|
Controls |
5,190 (2,271/3,019) |
4,740/444/6 (91.4/8.5/0.1) |
4.4 (4.0–4.8) |
|||
|
Overweight cases |
7,229 (4,496/2,733) |
6,589/629//11 (91.1/8.7/0.2) |
4.5 (4.2–4.9) |
0.7 |
0.8 |
1.02 (0.90–1.16) |
|
Obese cases |
4,928 (2,543/2,385) |
4,464/456/8 (90.5/9.3/0.2) |
4.8 (4.4–5.2) |
0.2 |
0.2 |
1.09 (0.95–1.25) |
|
Morbid obese cases |
399 (135/264) |
356/43/0 (89.1/10.9/0.0) |
5.4 (3.9–7.2) |
0.2 |
0.1 |
1.26 (0.91–1.74) |
|
CTNNBL1 rs6020846 |
n (men/women) |
Genotype distribution n AA/GA/GG (%) |
MAF (95% CI) |
padd |
pdom |
ORadd (95% CI) |
|
Controls |
5,188 (2,169/3,019) |
4,673/504/11 (90.1/9.7/0.2) |
5.1 (4.7–5.5) |
|||
|
Overweight cases |
7,204 (4,492/2,712) |
6,448/738/18 (89.4/10.3/0.2) |
5.4 (5.0–5.8) |
0.5 |
0.5 |
1.05 (0.93–1.18) |
|
Obese cases |
4,905 (2,533/2,372) |
4,358/531/16 (88.8/10.9/0.3) |
5.7 (5.3–6.2) |
0.06 |
0.06 |
1.13 (1.00–1.28) |
|
Morbid obese cases |
394 (134/260) |
348/46/0 (88.2/11.8/0.0) |
5.8 (4.3–7.7) |
0.3 |
0.2 |
1.17 (0.86–1.61) |
|
FDFT1 rs7001819 |
n (men/women) |
Genotype distribution n TT/TC/CC (%) |
MAF (95% CI) |
padd |
pdom |
ORadd (95% CI) |
|
Controls |
5,089 (2,123/2,966) |
2,084/2,367/638 (40.9/46.5/12.6) |
35.8 (34.9–36.7) |
|||
|
Overweight cases |
7,078 (4,391/2,687) |
2,843/3,281/954 (40.2/46.3/13.5) |
36.7 (35.9–37.5) |
0.5 |
0.6 |
1.02 (0.97–1.08) |
|
Obese cases |
4,810 (2,491/2,319) |
1,963/2,258/589 (40.6/47.1/12.3) |
35.7 (34.8–36.7) |
0.6 |
0.9 |
0.99 (0.93–1.05) |
|
Morbid obese cases |
387 (131/256) |
158/184/45 (41.0/47.5/11.5) |
35.4 (32.0–38.9) |
0.9 |
0.9 |
0.99 (0.85–1.16) |
|
|
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|
Data are number of subjects, divided into genotype groups (% in each group), frequencies of the minor allele (MAF) in percentages (95% CI) and odds ratio (OR) for an additive (add) model (95% CI). Since the CTNNBL1 variants are rather rare, the p-values are given for both an additive and dominant (dom) model. Differences in genotype distribution were evaluated using logistic regression. p-values were adjusted for age and sex. Controls were defined as BMI < 25 kg/m2, overweight cases as 25 kg/m2 ≤ BMI < 30 kg/m2, obese cases as BMI ≥ 30 kg/m2 and morbid obese cases as BMI ≥ 40 kg/m2. |
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|
Andreasen et al. BMC Medical Genetics 2009 10:17 doi:10.1186/1471-2350-10-17 |
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