Table 2

Results of the best SNPs in SH3PXD2B, SLIT3 and FLJ42133 as previously described [6] in two independent GWAs.

Case-control¹

KORA cohort²

Gene

SNP

Alleles³

MAF⁴cases/controls

Genotype distribution cases (%)/controls (%)

Odds ratio (95% CI)

Two-sided p-value

One-sided p-value

MAF

β (95% CI)

Two-sided p-value

One-sided p-value

SH3PXD2B

rs13356223

T/C

0.033/

0.032

454 (93.4)/

410 (93.8)

32(6.6)/

26 (6.0)

1 (0.2)

1.029

(0.614 – 1.722)

0.915

0.457

0.041

-0.549

(-1.235 – 0.136)

0.116

0.942

rs10077897

G/A

0.040/

0.036

447 (92.0)/

411 (93.0)

39 (8.0)/

30 (6.8)

1 (0.2)

1.114

(0.690 – 1.799)

0.658

0.329

0.046

-0.430

(-1.086 – 0.225)

0.198

0.901

rs13436547

G/A

0.033/

0.032

455 (93.4)/

415 (93.9)

32 (6.6)/

26 (5.9)

1 (0.2)

1.038

(0.620 – 1.739)

0.886

0.443

0.041

-0.486

(-1.172 – 0.201)

0.165

0.917

SLIT3

rs17734503

A/G

0.082/

0.072

409 (84.0)/

380 (86.0)

76 (15.6)/

60 (13.6)

2 (0.4)/

2 (0.4)

1.150

(0.814 – 1.626)

0.428

0.214

0.086

0.358

(-0.109 – 0.825)

0.133

0.066

rs12654448

C/T

0.079/

0.071

410 (84.4)/

381 (86.2)

75 (15.4)/

59 (13.3)

1 (0.2)/

2 (0.5)

1.126

(0.791 – 1.602)

0.510

0.255

0.088

0.125

(-0.352 – 0.601)

0.608

0.304

FLJ42133

rs7363432

A/G

0.066/

0.070

424 (87.1)/

383 (86.6)

62 (12.7)/

56/(12.7)

1 (0.2)/

3 (0.7)

0.932

(0.649 – 1.340)

0.704

0.648

0.057

0.234

(-0.369 – 0.837)

0.447

0.223

rs6095722

A/G

0.066/

0.070

422 (87.0)/

383 (86.6)

62 (12.8)/

56/(12.7)

1 (0.2)/

3 (0.7)

0.936

(0.651 – 1.346)

0.722

0.639

0.060

0.134

(-0.447 – 0.715)

0.651

0.325

¹described in Hinney et al., 2007 [7]

²described in Wichmann et al., 2008 [8]

³minor allele in bold

⁴MAF = minor allele frequency

Vogel et al. BMC Medical Genetics 2009 10:14 doi:10.1186/1471-2350-10-14