Table 2

SNPs associated with asthma or atopy with a FDR of 5% in the pooling-based GWA

SNP

Chromosome

Position

Comparison

p value

fAco-fAca

Region

Saturation


rs2501618

1

178225432

Atopy vs. controls

1.26 × 10-7

0.26

CEP350

No


rs4952590

2

42130425

Atopy vs. controls

4.63 × 10-7

0.19

SGK493 (LOC91461)

Yes


rs7629719

3

131642624

Atopy-Asthma vs. controls

1.11 × 10-7

0.21

COL29A1 (COL6A5)

Yes


rs9292961

5

20975886

Atopy vs. controls

5.38 × 10-7

0.3

Segmental Duplications

No


rs9376221

6

137034072

Atopy vs. controls

3.94 × 10-7

0.25

MAP3K5 (ASK1)

Yes


rs7843085

8

33235086

Atopy vs. controls

3.93 × 10-7

0.26

NT_007995.50

Yes


rs13273924

8

33246541

Atopy vs. controls

7.56 × 10-7

0.26

NT_007995.50

Yes


rs2330183

21

45777720

Atopy vs. controls

1.59 × 10-7

0.28

SLC19A1

Yes


fAco (allele frequency in controls); fAca (allele frequency in cases); CEP350: centrosomal protein 350 kDa; SGK493: protein kinase-like protein SgK493; COL29A1: collagen, type XXIX, alpha 1; MAP3K5: mitogen-activated protein kinase kinase kinase 5; ASK1: apoptosis signal-regulating kinase 1; SLC19A1: solute carrier family 19 (folate transporter), member 1

Castro-Giner et al. BMC Medical Genetics 2009 10:128   doi:10.1186/1471-2350-10-128

Open Data