Table 2 |
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|
Transmission (T) and non transmission (NT) of IFIH1 rs1990760 polymorphism in 100 Hashimoto's thyroiditis families (Italian) according to the presence of thyroid antibodies (TPO and TG) |
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|
Polymorphism |
Allele |
Frequency |
T |
NT |
p |
pc |
||
|
rs1990760 |
(%) |
n |
(%) |
n |
(%) |
|||
|
|
||||||||
|
Group |
A |
55.5 |
110 |
(49.5) |
112 |
(50.5) |
0.84 |
1.68 |
|
100 parents |
G |
44.5 |
90 |
(50.6) |
88 |
(49.4) |
||
|
|
||||||||
|
Group 1 |
A |
53.2 |
38 |
(45.8) |
45 |
(54.2) |
0.26 |
0.52 |
|
39 mo-, fa- |
G |
46.8 |
40 |
(54.8) |
33 |
(45.2) |
||
|
|
||||||||
|
Group 2 |
A |
57.9 |
41 |
(50.6) |
40 |
(49.4) |
0.86 |
1.72 |
|
35 mo+, fa- |
G |
42.1 |
29 |
(49.2) |
30 |
(50.8) |
||
|
|
||||||||
|
Group 3 |
A |
66.7 |
10 |
(41.7) |
14 |
(59.3) |
0.15 |
0.3 |
|
9 mo-, fa+ |
G |
33.3 |
8 |
(66.7) |
4 |
(33.3) |
||
|
|
||||||||
|
Group 4 |
A |
50.0 |
21 |
(61.8) |
13 |
(38.2) |
0.05*1 |
0.1 |
|
17 mo+, fa+ |
G |
50.0 |
13 |
(38.2) |
21 |
(61.8) |
||
|
|
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|
mo = mothers; fa = fathers pc = p corrected *1OR = odds ratio; (95% CI) = 95% confidence interval. group 4: allele A OR 2.61 (0.98-6.94) and allele G OR 0.38 (0.14-10.2) p = 0.05 |
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|
Penna-Martinez et al. BMC Medical Genetics 2009 10:126 doi:10.1186/1471-2350-10-126 |
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