Table 2 |
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|
Associations of obesity-related SNPs with BMI, change in BMI, and risk of becoming overweight |
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|
BMI (kg/m2) at baseline (1989) |
BMI change from age 21 to baseline (1989) |
BMI ≥25 kg/m2 at baseline (1989) among those with BMI <25 kg/m2 at age 21a |
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|
|
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|
Gene |
rs # |
Difference in meanb (95% CI) |
p-value |
Difference in meanb (95% CI) |
p-value |
Odds ratiob (95% CI) |
p-value |
|
|
|||||||
|
PPARG |
4684847 |
0.36 |
0.57 |
0.20 |
|||
|
CC |
Reference |
Reference |
1.00 (reference) |
||||
|
CT |
0.18 (-0.07, 0.43) |
-0.07 (-0.30, 0.15) |
1.06 (0.95, 1.20) |
||||
|
TT |
0.17 (-0.67, 1.02) |
0.30 (-0.45, 1.06) |
1.35 (0.91, 2.01) |
||||
|
PPARG |
709158 |
0.88 |
0.59 |
0.86 |
|||
|
AA |
Reference |
Reference |
1.00 (reference) |
||||
|
GA |
0.05 (-0.16, 0.27) |
0.09 (-0.10, 0.28) |
0.97 (0.88, 1.07) |
||||
|
GG |
0.02 (-0.29, 0.33) |
0.11 (-0.17, 0.39) |
0.99 (0.86, 1.14) |
||||
|
PPARG |
1175543 |
0.99 |
0.52 |
0.79 |
|||
|
AA |
Reference |
Reference |
1.00 (reference) |
||||
|
AG |
-0.01 (-0.22, 0.20) |
0.05 (-0.14, 0.24) |
0.97 (0.88, 1.07) |
||||
|
GG |
-0.03 (-0.34, 0.29) |
0.16 (-0.12, 0.44) |
0.99 (0.85, 1.14) |
||||
|
PPARG |
1801282 |
0.69 |
0.70 |
0.01 |
|||
|
CC |
Reference |
Reference |
1.00 (reference) |
||||
|
CG |
0.09 (-0.16, 0.34) |
-0.02 (-0.24, 0.20) |
1.03 (0.92, 1.16) |
||||
|
GG |
0.23 (-0.6, 1.06) |
0.31 (-0.44, 1.06) |
1.91 (1.28, 2.88) |
||||
|
PPARD |
2016520 |
0.61 |
0.40 |
0.54 |
|||
|
TT |
Reference |
Reference |
1.00 (reference) |
||||
|
CT |
-0.09 (-0.31, 0.12) |
-0.13 (-0.32, 0.06) |
0.97 (0.88, 1.07) |
||||
|
CC |
0.11 (-0.42, 0.64) |
-0.08 (-0.56, 0.39) |
1.10 (0.86, 1.41) |
||||
|
LPL |
316 |
0.39 |
0.55 |
0.78 |
|||
|
CC |
Reference |
Reference |
1.00 (reference) |
||||
|
AC |
0.07 (-0.17, 0.31) |
0.1 (-0.09, 0.29) |
1.03 (0.94, 1.14) |
||||
|
AA |
0.53 (-0.28, 1.34) |
0.01 (-0.28, 0.30) |
1.00 (0.86, 1.16) |
||||
|
PON1 |
662 |
0.61 |
0.59 |
0.75 |
|||
|
TT |
Reference |
Reference |
1.00 (reference) |
||||
|
CT |
-0.08 (-0.29, 0.12) |
0.10 (-0.11, 0.32) |
1.04 (0.93, 1.17) |
||||
|
CC |
-0.14 (-0.51, 0.22) |
-0.12 (-0.85, 0.60) |
0.96 (0.65, 1.40) |
||||
|
LEPR |
7602 |
0.47 |
0.71 |
0.34 |
|||
|
GG |
Reference |
Reference |
1.00 (reference) |
||||
|
AG |
-0.14 (-0.35, 0.08) |
-0.06 (-0.24, 0.13) |
0.93 (0.85, 1.02) |
||||
|
AA |
-0.05 (-0.55, 0.45) |
0.07 (-0.26, 0.39) |
0.98 (0.83, 1.16) |
||||
|
LEPR |
1045895 |
0.69 |
0.01 |
0.12 |
|||
|
GG |
Reference |
Reference |
1.00 (reference) |
||||
|
AG |
0.08 (-0.14, 0.30) |
-0.28 (-0.47, -0.09) |
0.93 (0.84, 1.03) |
||||
|
AA |
-0.02 (-0.31, 0.28) |
-0.30 (-0.75, 0.15) |
1.16 (0.92, 1.48) |
||||
|
LEPR |
1137101 |
0.02 |
0.04 |
0.39 |
|||
|
AA |
Reference |
Reference |
1.00 (reference) |
||||
|
AG |
-0.18 (-0.41, 0.05) |
0.22 (0.03, 0.42) |
1.07 (0.97, 1.19) |
||||
|
GG |
0.18 (-0.11, 0.46) |
0.26 (0.00, 0.53) |
1.05 (0.92, 1.21) |
||||
|
PON2 |
7493 |
0.50 |
0.18 |
0.27 |
|||
|
GG |
Reference |
Reference |
1.00 (reference) |
||||
|
CG |
0.02 (-0.19, 0.23) |
-0.17 (-0.38, 0.04) |
0.94 (0.85, 1.05) |
||||
|
CC |
0.27 (-0.18, 0.72) |
0.00 (-0.26, 0.25) |
1.03 (0.90, 1.18) |
||||
|
PON2 |
12026 |
0.59 |
0.64 |
0.05 |
|||
|
CC |
Reference |
Reference |
1.00 (reference) |
||||
|
CG |
0.03 (-0.18, 0.24) |
0.08 (-0.10, 0.27) |
1.08 (0.98, 1.19) |
||||
|
GG |
0.23 (-0.22, 0.68) |
0.11 (-0.29, 0.51) |
1.25 (1.02, 1.55) |
||||
|
TNFα |
1800629 |
0.27 |
0.56 |
0.07 |
|||
|
GG |
Reference |
Reference |
1.00 (reference) |
||||
|
GA |
0.15 (-0.07, 0.38) |
0.09 (-0.09, 0.28) |
1.08 (0.98, 1.19) |
||||
|
AA |
-0.22 (-0.82, 0.39) |
0.13 (-0.27, 0.54) |
1.23 (1.00, 1.51) |
||||
|
TNFα |
1799724 |
0.19 |
0.19 |
0.06 |
|||
|
CC |
Reference |
Reference |
1.00 (reference) |
||||
|
CT |
-0.24 (-0.50, 0.02) |
0.19 (-0.01, 0.38) |
1.11 (1.00, 1.23) |
||||
|
TT |
0.11 (-0.91, 1.13) |
0.07 (-0.47, 0.62) |
0.84 (0.63, 1.12) |
||||
|
TNFα |
1799964 |
0.06 |
0.31 |
0.87 |
|||
|
TT |
Reference |
Reference |
1.00 (reference) |
||||
|
CT |
0.22 (0.01, 0.43) |
-0.18 (-0.42, 0.06) |
1.01 (0.89, 1.14) |
||||
|
CC |
-0.16 (-0.61, 0.29) |
0.11 (-0.81, 1.03) |
0.88 (0.55, 1.40) |
||||
|
MAOA (F) |
1801291 |
0.45 |
0.30 |
0.82 |
|||
|
CC |
Reference |
Reference |
1.00 (reference) |
||||
|
CT |
0.16 (-0.13, 0.45) |
0.10 (-0.09, 0.29) |
1.02 (0.93, 1.13) |
||||
|
TT |
-0.10 (-0.61, 0.42) |
-0.19 (-0.60, 0.21) |
0.96 (0.78, 1.18) |
||||
|
MAOA (M) |
1801291 |
NA |
NA |
NA |
|||
|
CC |
Reference |
Reference |
1.00 (reference) |
||||
|
TT |
-0.07 (-0.36, 0.22) |
0.08 (-0.17, 0.33) |
1.02 (0.90, 1.15) |
||||
|
|
|||||||
|
95% CI, 95% confidence interval; NA, not applicable a n = 7970 with self-reported BMI < 25 kg/m2 at age 21 b Adjusted for age and gender |
|||||||
|
Gallicchio et al. BMC Medical Genetics 2009 10:103 doi:10.1186/1471-2350-10-103 |
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