Additional file 3.

ROC curves using Membrane Isolation Algorithm based on k = 15 and a combination (k = 15, k = 5). This is a comparison of ROC curves based on different Membrane Isolation Algorithm (MIA) variations. Since lighter cases showed enhanced membrane isolation detection when lower thresholds were used, a MIA using k = 5 threshold for lighter images and k = 15 for darker images was evaluated (green line). However, this did not improve AUC in comparison to one universal threshold (black line), and consequently, only one threshold (k = 15) was used in the results of this manuscript. It is interesting to note that the combination threshold used had very similar results to manual scoring (blue line).

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Hall et al. BMC Medical Imaging 2008 8:11   doi:10.1186/1471-2342-8-11