Table 3

The intra-observer repeatability and variability (N = 30) for FA and ADC (10-3mm2/s) (N = 30)
Circular ROI Freehand ROI
Mean diff. ± 2sd Mean diff. ± 2sd
Region Parameter ICC p CV (%) ICC p CV (%)
Basal pons FA 0.74 < 0.001* 10.4 0.020 ± 0.093 0.63 < 0.001* 9.5 −0.061 ± 0.085
ADC 0.83 < 0.001* 7.9 −0.010 ± 0.038 0.70 0.001* 6.0 0.004 ± 0.082
Cerebral peduncle FA 0.74 < 0.001* 5.9 0.006 ± 0.092 0.42 0.025 5.6 −0.038 ± 0.101
ADC 0.19 0.297 7.6 0.001 ± 0.145 0.29 0.141 6.1 0.030 ± 0.120
Internal capsule, post FA 0.90 < 0.001* 5.5 −0.002 ± 0.049 0.66 < 0.001* 5.7 −0.043 ± 0.051
ADC 0.76 < 0.001* 3.5 0.006 ± 0.042 0.78 < 0.001* 2.3 −0.002 ± 0.027
Corona radiata FA 0.84 < 0.001* 10.2 0.005 ± 0.077 0.86 < 0.001* 9.2 −0.013 ± 0.063
ADC 0.76 < 0.001* 4.2 −0.004 ± 0.048 0.86 < 0.001* 3.6 0.008 ± 0.030
Centrum semiovale FA 0.48 0.041 13.1 −0.001 ± 0.160 0.26 0.121 9.5 −0.051 ± 0.128
ADC 0.63 0.005 5.5 −0.005 ± 0.079 0.87 < 0.001* 3.1 0.005 ± 0.028
Uncinate fasciculus FA 0.67 0.002* 10.7 0.007 ± 0.116 0.61 < 0.001* 7.6 −0.051 ± 0.051
ADC 0.69 0.001* 4.1 0.000 ± 0.063 0.92 < 0.001* 3.7 −0.003 ± 0.031
Forceps minor FA 0.76 < 0.001* 12.2 −0.009 ± 0.118 0.65 < 0.001* 9.1 −0.044 ± 0.067
ADC 0.64 0.005 4.6 −0.001 ± 0.073 0.89 < 0.001* 3.7 0.001 ± 0.035
Ant corona radiata FA 0.71 0.001* 12.8 0.009 ± 0.133 0.61 < 0.001* 8.3 −0.036 ± 0.073
ADC 0.27 0.169 3.7 −0.017 ± 0.071 0.85 < 0.001* 3.7 −0.002 ± 0.040
CC genu FA 0.67 0.002* 4.7 0.008 ± 0.078 0.15 0.002* 5.7 −0.137 ± 0.082
ADC 0.93 < 0.001* 7.7 −0.008 ± 0.062 0.37 0.001* 6.5 0.089 ± 0.102
CC body FA 0.23 0.203 5.8 0.027 ± 0.112 0.59 < 0.001* 9.0 −0.067 ± 0.091
ADC 0.26 0.107 9.8 −0.085 ± 0.195 0.50 0.002* 9.8 0.087 ± 0.166
CC splenium FA 0.89 < 0.001* 6.1 0.002 ± 0.066 0.27 0.006 6.0 −0.094 ± 0.100
ADC 0.82 < 0.001* 6.6 −0.001 ± 0.075 0.34 0.015 5.9 0.060 ± 0.099

ICC = intra-class correlation coefficient; CV = coefficient of variation; Mean diff. ± 2sd = 95% limits of agreement, * = the statistical significance p < 0.05/11 with Bonferroni correction for 11 regions.

Hakulinen et al.

Hakulinen et al. BMC Medical Imaging 2012 12:30   doi:10.1186/1471-2342-12-30

Open Data