Table 2

Measurements by observer 2 (mean ± sd), inter-observer repeatability (Obs. 1: 2. meas.) and variation (N = 30) for FA and ADC (10-3mm2/s)
Circular ROI Freehand ROI
Region Parameter Mean ± SD ICC p CV(%) Mean ± SD ICC p CV(%)
Basal pons FA 0.705 ± 0.044 0.44 0.004* 8.6 0.621 ± 0.061 0.73 < 0.001* 9.2
ADC 0.726 ± 0.069 0.24 0.226 8.9 0.730 ± 0.080 0.01 0.487 8.4
Cerebral peduncle FA 0.850 ± 0.035 0.62 0.006 4.9 0.788 ± 0.062 0.14 0.319 6.4
ADC 0.706 ± 0.048 0.56 0.018 7.0 0.772 ± 0.070 0.49 0.008 6.8
Internal capsule, post FA 0.767 ± 0.046 0.67 < 0.001* 5.6 0.728 ± 0.036 0.80 < 0.001* 5.0
ADC 0.696 ± 0.034 0.63 0.001* 4.2 0.693 ± 0.021 0.84 < 0.001* 2.8
Corona radiata FA 0.508 ± 0.038 0.54 0.023 8.6 0.515 ± 0.047 0.78 < 0.001* 9.0
ADC 0.648 ± 0.030 0.64 0.005 4.5 0.665 ± 0.025 0.93 < 0.001* 3.6
Centrum semiovale FA 0.501 ± 0.067 0.64 0.004* 14.5 0.509 ± 0.051 0.47 0.007 9.9
ADC 0.700 ± 0.042 0.75 < 0.001* 6.0 0.693 ± 0.024 0.86 < 0.001* 3.3
Uncinate fasciculus FA 0.529 ± 0.060 0.62 0.007 11.7 0.517 ± 0.050 0.74 < 0.001* 8.5
ADC 0.779 ± 0.036 0.55 0.018 4.4 0.768 ± 0.025 0.84 < 0.001* 3.7
Forceps minor FA 0.545 ± 0.057 0.64 0.004* 12.0 0.499 ± 0.051 0.83 < 0.001* 9.5
ADC 0.762 ± 0.046 0.17 0.319 5.1 0.757 ± 0.029 0.88 < 0.001* 3.7
Ant corona radiata FA 0.551 ± 0.073 0.84 < 0.001* 13.7 0.497 ± 0.040 0.86 < 0.001* 8.3
ADC 0.754 ± 0.029 0.45 0.060 3.8 0.748 ± 0.024 0.82 < 0.001* 3.5
CC genu FA 0.836 ± 0.034 0.80 < 0.001* 4.2 0.785 ± 0.051 0.51 0.013 5.3
ADC 0.765 ± 0.044 0.80 < 0.001* 6.2 0.846 ± 0.069 0.37 0.012 7.3
CC body FA 0.696 ± 0.057 0.39 0.066 6.7 0.654 ± 0.069 0.62 0.003* 9.8
ADC 0.821 ± 0.164 0.61 0.008 15 0.862 ± 0.114 0.65 0.001* 12.2
CC splenium FA 0.864 ± 0.047 0.90 < 0.001* 5.6 0.838 ± 0.043 0.88 < 0.001* 5.2
ADC 0.717 ± 0.038 0.81 < 0.001* 5.4 0.739 ± 0.039 0.80 < 0.001* 5.5

* = the statistical significance p < 0.05/11 with Bonferroni correction for 11 regions.

ICC = intra-class correlation coefficient; CV = coefficient of variation.

Hakulinen et al.

Hakulinen et al. BMC Medical Imaging 2012 12:30   doi:10.1186/1471-2342-12-30

Open Data