Table 4

Therapy of immunosuppressed mice by WNIG.

Treatment group

Survival % (live/treated)

WNV control

58 (7/12)

Dexamethasone

19 (3/16)^a

Dex + WNIG (1.0 mg/mouse)

100 (17/17)

Dex + WNIG (0.2 mg/mouse)

100 (16/16)

Group of 7–8 week-old BALB/c mice received two s.c. injection of 60 μg/mouse, dexamethasone (Dex), 2 hours before, and one day after infection with WNV. Mice were treated i.p. with WNIG (1.0 or 0.2 mg/mouse), 4 h after infection with 5–10 PFU of WNV. Mice were observed daily for mortality for 21 days. No mortality was observed in no-infected dexamethasone-treated mice.

^ap < 0.001, as compared to the WNIG (0.2–1.0 mg) group.

Ben-Nathan et al. BMC Infectious Diseases 2009 9:18   doi:10.1186/1471-2334-9-18