Table 2

Estimated risk of a validated medically attended local reaction by age at Td vaccination.

Age group, years

Number Td vaccinations

Estimated1 number of medically attended local reactions

Estimated event risk (95% CI) per 10,000 Td vaccinations2


9-10

21,188

13

6.3 (3.4, 11.5)

11-15

310,803

88

2.8 (2.1, 3.7)

16-20

65,971

24

3.6 (2.3, 5.6)

21-25

38,866

34

8.7 (4.9, 15.7)

All

436,828

159

3.6 (2.8, 4.7)


CI = confidence interval

1The number of events estimated based on multiple imputation applied to account for incomplete chart reviews.

2Compared with the 11-15 year old age group, the risk was significantly higher in the 9-10 year old age group (p = 0.01) and the 21-25 year old age group (p = 0.005). The risk among 21-25 year olds was also significantly higher than among 16-20 year olds (p = 0.01).

Jackson et al. BMC Infectious Diseases 2009 9:165   doi:10.1186/1471-2334-9-165

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