Table 2

Vaccination status, pneumococcal carriage by serotype, recent antibiotic use and carriage of non-susceptible pneumococci, by year

Year

2003

2005

No. communities

29

17

No. children swabbed

902

818

Children (%)

Risk Difference

P

Vaccinated (>1 dose)

87%

96%

9% [7,12]

0.0000

Vaccinated (primary)

76%

84%

9% [5,12]

0.0000

Vaccinated (primary+23v)

35%

62%

27% [22,31]

0.0000


Spn (% children)

82%

76%

-6% [-10,-2]

0.002

0–6 mo n = 83

83%

74%

-9.7 [-28,8]

0.3098

6–12 mo n = 220

80%

78%

-1.6 [-13,10]

0.7791

12–24 mo n = 477

84%

76%

-8.2 [-16, -0.2]

0.0331

24–48 mo n = 597

84%

78%

-5.3 [-12,1]

0.0989

48- n = 343

77%

74%

-2.9 [-13,7]

0.5677

7PCV-type

11%

8%

-4% [-6, -0.1]

0.0105

23PPV-type

42%

33%

-9% [-14,-5]

0.0001

23PPV-type, non-7PCV

31%

25%

-6% [-10,-2]

0.0061

19A

12%

9%

-3% [-6,-1]

0.0196

Non-23PPV

57%

67%

9% [5,14]

0.0001

6A

4%

2%

-1.5% [-3,0.1]

0.0712

6C

4%

4%

0% [-2,2]

0.9634

16F

12%

10%

-2% [-5,1]

0.1343


Prescribed beta-lactam

14%

16%

1% [-2,5]

0.4763

Penicillin non-susceptible (MIC ≥ 0.12 μg/mL)

17%

14%

-3% [-6,0.4]

0.0899

Prescribed macrolide

1%

6%

5% [3,7]

0.0000

Azithromycin resistant (MIC ≥ 2 μg/mL)

5%

6%

1% [-1,3]

0.4888

Azithromycin resistant (MIC ≥ 32 μg/mL)

4%

3%

-1% [-3,1]

0.2328


Leach et al. BMC Infectious Diseases 2009 9:121   doi:10.1186/1471-2334-9-121

Open Data