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Open AccessHighly AccessResearch article

Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity

Fernando A Bozza1 email, Oswaldo G Cruz2 email, Sonia MO Zagne3 email, Elzinandes L Azeredo4 email, Rita MR Nogueira5 email, Edson F Assis6 email, Patricia T Bozza6 email and Claire F Kubelka4 email

Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil

Programa de Computação Científica, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil

Hospital Universitário Antonio Pedro, Universidade Federal Fluminense, Niterói, Brazil

Laboratório de Imunologia Viral, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil

Laboratório de Flavivirus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil

Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil

author email corresponding author email

BMC Infectious Diseases 2008, 8:86doi:10.1186/1471-2334-8-86

Published: 25 June 2008

Additional files

Additional file 1:

Blood collection time in patients during dengue fever. Twenty patients had mild dengue and thirty-nine had severe dengue. Box-and-whiskers graph. The box extends from the 25th to the 75th percentile and the line at the middle is the median. The error bars, or whiskers extend down to the lowest value and up to the highest. Mann-Whitney U test was used to evaluate differences between blood collection time from severe and mild dengue patients and no significant difference was found (P = 0.7851).

Format: BMP Size: 739KB Download file

Additional file 2:

Time dependent cytokine levels in plasma from patients with mild and severe dengue. Twenty patients had mild dengue and thirty-nine had severe dengue. Dots represent single patient's cytokine measurements.

Format: BMP Size: 1MB Download file


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