Table 1 |
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|
Correlation between baseline immunological parameters and CD4 count change from baseline to nadir during TI |
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|
T-cell compartment |
Proliferative Stimulus/Phenotypic Markers Expression* |
Correlation with CD4 count change from baseline to nadir during TI** |
|
|
||
|
CD4 |
anti-CD3 |
-0.07 (p = 0.87) |
|
SEB |
0.43 (p = 0.30) |
|
|
CMV |
-0.59 (p = 0.045)*** |
|
|
Gag p55 peptide pool |
-0.40 (p = 0.17) |
|
|
%CD57+ |
-0.69 (p = 0.0095)*** |
|
|
CD57+ MFI |
-0.03 (p = 0.93) |
|
|
%CD28 |
-0.38 (p = 0.19) |
|
|
CD28+ MFI |
-0.18 (p = 0.55) |
|
|
CD8 |
anti-CD3 |
-0.09 (p = 0.81) |
|
SEB |
0.14 (p = 0.75) |
|
|
CMV |
-0.48 (p = 0.12) |
|
|
Gag p55 peptide pool |
-0.01 (p = 0.96) |
|
|
%CD57+ |
0.01 (p = 0.97) |
|
|
CD57+ MFI |
0.29 (p = 0.34) |
|
|
%CD28 |
0.33 (p = 0.27) |
|
|
CD28+ MFI |
-0.10 (p = 0.73) |
|
|
Baseline CD4+ count |
-0.61 (p = 0.030)*** |
|
|
Baseline viral load |
-0.35 (p = 0.24) |
|
|
|
||
|
*CMV = cytomegalovirus lysate; SEB = streptococcus enterotoxin B; MFI = mean fluorescence intensity. **Spearman nonparametric correlation test (p-value). ***p < 0.05 |
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|
Huang et al. BMC Infectious Diseases 2008 8:59 doi:10.1186/1471-2334-8-59 |
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