Table 4

NP isolates and resistance to TMP-SMX and other selected antimicrobials

Organisms isolated

Resistant to TMP-SMX

Resistance to selected antibiotics


S. pneumoniae

43 (89.6%)

Pen 20 (41.7%)# CTX 1 (2.1%)

Gram negative respiratory

H. influenzae

20 (80%)

Amp 3 (12%); Amox/clav 1 (4%)

M. catarrhalis

2 (18.2%) Δ

† Beta-lactamase +ve 12 (85.7%)

S. aureus

40 (91%)

Clox – 34 (77.3%) Gent 36 (81.8%), Amik – 0

Enterobacteriaceae

29 (90.6%)

CTX 16 (50%); Gent 18 (56%); Amik 5 (15.6%); PTZ 10 – 31.3%) Mero – 0

Pseudomonas

0

Gent – 1 (20%); Amik – 0


Clox – cloxacillin, Gent – gentamicin, Amik – amikacin, Pen – penicillin; CTX – cefotaxime; Amp – ampicillin, Amox/clav – amoxicillin-clavulanate

# S. pneumoniae – MIC performed in 18 isolates: 7 (38.9%) fully sensitive (MIC ≤ 0.06 μg/ml) 9 (50%) with intermediate resistance (MIC 0.12 – 1 μg/ml) and 2 (11.1%) with high level resistance (MIC ≥2 mg/ml) to penicillin

M. catarrhalis: Δ 11 isolates tested for MIC; † 14 of 17 isolates tested for beta-lactamase production. No significant differences for resistance to penicillin, cloxacillin, cefotaxime, gentamicin, amikacin and TMP-SMX by present or previous exposure to TMP-SMX

Cotton et al. BMC Infectious Diseases 2008 8:40   doi:10.1186/1471-2334-8-40

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