|
Potential sepsis related markers (modified from reference 18) |
| General Variables |
| Temperature > 38.3°C or < 36°C |
| Heart rate > 90 beats min-1 |
| Tachypnea (respiratory rate > 20 breaths min-1 in adults) |
| Altered mental status |
| Inflammatory variables |
| WBC > 12,000 μL-1, < 4,000 μL-1 or with > 10% immature forms |
| Plasma C-reactive protein > 2 SD above the normal value |
| Plasma procalcitonin > 2 SD above the normal value |
| Hemodynamic variables |
| Systolic blood pressure < 90 mm Hg or mean arterial blood pressure < 70 mm Hg |
| Mixed venous oxygen saturation > 70% |
| Cardiac index > 3.5 L*min-1*M-23 |
| Organ dysfunction variables |
| PaO2/FIO2 < 300 |
| Urine output < 0.5 mL*kg-1*hr-1 or creatinine increase > 0.5 mg/dL |
| International normalized ratio (INR) > 1.5 or aPTT > 60 secs |
| Platelet count < 100,000 μL-1 |
| Plasma total bilirrubin > 4 mg/Dl |
| Tissue perfusion variables |
| Hyperlactatemia > 1 mmol/L |
| Decreased capillary refill or mottling |
De La Rosa et al. BMC Infectious Diseases 2008 8:18 doi:10.1186/1471-2334-8-18 |