|
Sample of erroneous answers discovered in databases |
||||
| Category |
Question |
Correct answer used for assessment |
Erroneous answer(s) |
Database(s) |
|
|
||||
| Dosing |
What is the recommended dosing regimen for fosamprenavir in a protease inhibitor-experienced HIV+ patient who wants once daily dosing? |
Once daily dosing is not recommended for this type of patient |
• 700 mg by mouth once daily plus ritonavir 100 mg twice daily for PI experienced patients |
• PPDC |
|
|
||||
| Adverse Drug Reaction |
Can ethionamide cause impotence? |
Yes, but it is a rare ADR. |
• Listed as a common reaction |
• JHAG |
|
|
||||
| Method of Administration |
How do you administer Synagis? |
Remove flip top from Synagis vial and wipe rubber stopper with a disinfectant (e.g., 70% isopropyl alcohol). Insert needle into vial, and withdraw into syringe an appropriate volume of solution. Administer immediately after drawing dose into syringe. Synagis is supplied as single-dose vial and does not contain preservatives. Do not re-enter vial after withdrawal of drug; discard unused portion. Only administer one dose per vial. |
• Provides information about scheduling multiple patients for multiple injections from same vial to minimize waste |
• CP |
|
|
||||
| Indication |
Should amantadine be given as prophylaxis against influenza A? |
It should not be used in the 2007–2008 influenza season due to resistance. |
• Provides pediatric dosing information for this indication • Lists influenza A prophylaxis as an indication |
• PPDC • DM • IDI |
|
|
||||
| Drug-Food interaction |
How should didanosine be taken in regards to food? |
Didanosine should be taken on an empty stomach at least 30 minutes before or 2 hours after food. Do not take didanosine or didanosine EC with food. |
• Provides contradictory information: States that didanosine can be taken with or without food in one sentence and the following statement states to take on an empty stomach 30 minutes before or 2 hours after food. |
• EOF • EOP • DIO |
|
CP = Clinical Pharmacology; DIO = DIOne; DM = DailyMed; EOF = Epocrates Online Free; EOP = Epocrates Online Premium; IDI = Internet Drug Index; JHAG = Johns Hopkins ABX Guide; PPDC = PEPID PDC | ||||
Polen et al. BMC Infectious Diseases 2008 8:153 doi:10.1186/1471-2334-8-153 |
||||