Figure 1.

Dose effect. The optimal dose of ATL313 was determined through a dose response curve where PBS vehicle (white diamond), 5 μg/kg ATL313 (black circle), 50 μg/kg ATL313 (black triangle), 100 μg/kg ATL313 (white square), or 200 μg/kg ATL313 (asterix) was injected IP every 6 hours into BALB/c mice (N = 4 per group) after a lethal IP dose of LPS O111:B4 (20 mg/kg).