Table 3 |
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|
Multivariable Cox Proportional Hazards Models |
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|
Outcome = In-hospital Mortality |
Outcome = Length of Stay |
|
|
|
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|
Variable |
Hazard Ratio (95% CI) |
Hazard Ratio (95% CI) |
|
|
||
|
All Bacteremias (N = 416) |
||
|
Appropriate Antibiotics -8 to 24 hours |
1.03 (0.60 to 1.78) |
1.11 (0.86 to 1.44) |
|
Age (per year) |
1.02 (1.01 to 1.04) |
NS |
|
Male Sex |
-- |
NS |
|
Central line at time of culture |
-- |
0.67 (0.54 to 0.85) |
|
Time at risk† (per day) |
NS |
0.66 (0.52 to 0.83) |
|
APS 24 hours before culture |
1.06 (1.05 to 1.08) |
0.99 (0.97 to 0.99) |
|
Polymicrobial bacteremia |
NS |
-- |
|
E. coli Bacteremia (N = 225) |
||
|
Appropriate Antibiotics -8 to 24 hours |
1.11 (0.52 to 2.34) |
1.04 (0.72 to 1.51) |
|
Central line at time of culture |
NS |
NS |
|
Time at risk† |
NS |
0.66 (0.47 to 0.91) |
|
APS 24 hours before culture |
1.06 (1.04 to 1.08) |
0.98 (0.97 to 1.00) |
|
Polymicrobial bacteremia |
NS |
-- |
|
Klebsiella Bacteremia (N = 203) |
||
|
Appropriate Antibiotics -8 to 24 hours |
0.84 (0.42 to 1.70) |
1.21 (0.84 to 1.73) |
|
Age |
1.03 (1.01 to 1.06) |
-- |
|
Time at risk† |
-- |
0.65 (0.47 to 0.90) |
|
Central line at time of culture |
-- |
0.62 (0.44 to 0.86) |
|
APS 24 hours before culture |
1.06 (1.03 to 1.09) |
0.98 (0.97 to 1.00) |
|
|
||
|
APS – modified acute physiology score NS – not significant (p > 0.05) -- Not included in final model †Time at risk is the time from hospital admission to index culture collection NB: Hazard Ratios are reported per one unit increase in the study variable; for example a HR of 1.06 for APS can be interpreted as a 6% increase in the hazard of death for each one unit increase in APS; therefore for an increase in APS of 5 points the hazard of death would increase by 30%. |
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|
Thom et al. BMC Infectious Diseases 2008 8:116 doi:10.1186/1471-2334-8-116 |
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