Table 1

Sources, experimental models, and scoring criteria for Mycobacterium tuberculosis DNA microarray gene expression and genome-wide gene knock-out (growth phase essentiality) data used in this study.

Reference
Experimental model
Timepoint: Maximum scorea

Betts et al., 2002 [116]
Starvation under controlled O2
96 h: 3
24 h: 2
4 h: 1
Hampshire et al., 2004 [30]
Nutrient depletion under controlled O2
62 and 75 d: 5
49 d: 4
18 d: 2
Muttucumaru et al., 2004 [115]
Wayne model of hypoxia [8]
14 d (NRP-2): 4
7 d (NRP-1): 2
Voskuil et al. 2004 [31]
Wayne model of hypoxia [8]
30 and 80 d: 5
14 and 20 d: 4
10 and 12 d: 3
6 and 8 d: 2
Schnappinger et al. 2003 [29]
Infection of mouse macrophages, +/- γ-INF
24 and 48 h: 5
Karakousis et al., 2004 [117]
Hollow fiber subcutaneous implant in mice
10 d: 3
Talaat et al., 2004 [118]
Infection of mice. MTB harvested from lungb
28 d: 3
Sassetti et al. 2003a [13]
TraSH mutated libraries grown on solid media
14 d:5
Rengarajan et al. 2005 [12]
Infection of mouse macrophages, +/- γ-INF with TraSH mutated libraries of M. tuberculosis
7 d: 5
Sassetti et al. 2003b [14]
C57BL/6J mice infected with TraSH mutated libraries of M. tuberculosis
7, 14, 28 and 56 d: 5

Footnotes

aMaximum score based on relevance as a dormancy model.

bRatio of M. tuberculosis from Balb/c lung to MTB in aerated culture for 28 d.

Murphy and Brown BMC Infectious Diseases 2007 7:84   doi:10.1186/1471-2334-7-84