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Sources, experimental models, and scoring criteria for Mycobacterium tuberculosis DNA microarray gene expression and genome-wide gene knock-out (growth phase essentiality) data used in this study. |
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| Reference |
Experimental model |
Timepoint: Maximum scorea |
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| Betts et al., 2002 [116] |
Starvation under controlled O2 |
96 h: 3 24 h: 2 4 h: 1 |
| Hampshire et al., 2004 [30] |
Nutrient depletion under controlled O2 |
62 and 75 d: 5 49 d: 4 18 d: 2 |
| Muttucumaru et al., 2004 [115] |
Wayne model of hypoxia [8] |
14 d (NRP-2): 4 7 d (NRP-1): 2 |
| Voskuil et al. 2004 [31] |
Wayne model of hypoxia [8] |
30 and 80 d: 5 14 and 20 d: 4 10 and 12 d: 3 6 and 8 d: 2 |
| Schnappinger et al. 2003 [29] |
Infection of mouse macrophages, +/- γ-INF |
24 and 48 h: 5 |
| Karakousis et al., 2004 [117] |
Hollow fiber subcutaneous implant in mice |
10 d: 3 |
| Talaat et al., 2004 [118] |
Infection of mice. MTB harvested from lungb |
28 d: 3 |
| Sassetti et al. 2003a [13] |
TraSH mutated libraries grown on solid media |
14 d:5 |
| Rengarajan et al. 2005 [12] |
Infection of mouse macrophages, +/- γ-INF with TraSH mutated libraries of M. tuberculosis |
7 d: 5 |
| Sassetti et al. 2003b [14] |
C57BL/6J mice infected with TraSH mutated libraries of M. tuberculosis |
7, 14, 28 and 56 d: 5 |
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Footnotes aMaximum score based on relevance as a dormancy model. bRatio of M. tuberculosis from Balb/c lung to MTB in aerated culture for 28 d. | ||
Murphy and Brown BMC Infectious Diseases 2007 7:84 doi:10.1186/1471-2334-7-84 |
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