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Open Access Research article

Oral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain

Mark E Wickham14, Nat F Brown15, John Provias2, B Brett Finlay1 and Brian K Coombes3*

Author Affiliations

1 Michael Smith Laboratories, University of British Columbia, Vancouver, BC., Canada

2 Department of Neuropathology, Hamilton Health Sciences Corporation, Hamilton, ON., Canada

3 Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada, and the Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, Guelph, ON., Canada

4 Phillips Ormonde Fitzpatrick, Level 21, 367 Collins Street, Melbourne 3000, Australia

5 Institute for Glycomics, Griffith University-Gold Coast Campus, PMB 50, Gold Coast Mail Centre, Gold Coast, Queensland 9726, Australia

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BMC Infectious Diseases 2007, 7:65  doi:10.1186/1471-2334-7-65

Published: 27 June 2007

Abstract

Background

Salmonella meningitis is a rare and serious infection of the central nervous system following acute Salmonella enterica sepsis. For this pathogen, no appropriate model has been reported in which to examine infection kinetics and natural dissemination to the brain.

Methods

Five mouse lines including C57BL/6, Balb/c, 129S6-Slc11a1tm1Mcg, 129S1/SvImJ, B6.129-Inpp5dtm1Rkh were used in the murine typhoid model to examine the dissemination of systemic Salmonella enterica serovar Typhimurium following oral infection.

Results

We report data on spontaneous meningitis and brain infection following oral infection of mice with Salmonella enterica serovar Typhimurium.

Conclusion

This model may provide a system in which dissemination of bacteria through the central nervous system and the influence of host and bacterial genetics can be queried.