|
Frequency of occurrence of daptomycin MIC values for key Gram-positive pathogens. |
|||||||
| No. (%) of isolates inhibited at daptomycin MIC (mg/L) of: |
|||||||
|
|
|||||||
| Organism (no. tested) |
≤0.06 |
0.12 |
0.25 |
0.5 |
1 |
2 |
4 |
|
|
|||||||
| S. aureus (2,746) |
3 (0.1) |
90 (3.3) |
1.798 (65.5) |
835 (30.4) |
20 (0.7) |
- |
- |
| Oxacillin-susceptible (1,946) |
2 (0.1) |
75 (3.9) |
1,376 (70.7) |
485 (24.9) |
8 (0.4) |
- |
- |
| Oxacillin-resistant (800) |
1 (0.1) |
15 (1.9) |
422 (52.8) |
350 (43.8) |
12 (1.5) |
- |
- |
| Coagulase-negative staphylococci (941) |
13 (1.4) |
72 (7.7) |
447 (47.5) |
381 (40.5) |
27 (2.9) |
- |
1 (0.1)a |
| Oxacillin-susceptible (268) |
6 (2.2) |
30 (11.2) |
129 (48.1) |
90 (33.6) |
12 (4.5) |
- |
1 (0.4)a |
| Oxacillin-resistant (673) |
7 (1.0) |
42 (6.2) |
318 (47.3) |
291 (43.2) |
15(2.2) |
- |
- |
| E. faecalis (646) |
2 (0.3) |
2 (0.3) |
34 (5.3) |
303 (46.9) |
291 (45.0) |
14 (2.2) |
- |
| Vancomycin-susceptible (640) |
2 (0.3) |
2 (0.3) |
34 (5.3) |
299 (46.7) |
289 (45.2) |
14 (2.2) |
- |
| Vancomycin-non-susceptible (6) |
- |
- |
- |
4 (66.7) |
2 (33.3) |
- |
- |
| E. faecium (307) |
- |
1 (0.3) |
3 (1.0) |
19 (6.2) |
72 (23.5) |
151 (49.2) |
61 (19.9) |
| Vancomycin-susceptible (252) |
- |
1 (0.4) |
3 (1.2) |
18 (7.1) |
60 (23.8) |
120 (47.6) |
50 (19.8) |
| Vancomycin-non-susceptible (55) |
- |
- |
- |
1 (1.8) |
12 (21.8) |
31 (56.4) |
11 (20.0) |
|
a. Single strain of MS-CoNS. | |||||||
Sader et al. BMC Infectious Diseases 2007 7:29 doi:10.1186/1471-2334-7-29 |
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