Open Access Open Badges Research article

Disease burden and related medical costs of rotavirus infections in Taiwan

Chun-Yi Lu1, Tsai-Ling Lauderdale2, Yin-Hua Fang3, Chung-Yi Wang1, Yu-Huai Ho4, Che-Lun Hung2, Luan-Yin Chang1, Chin-Yun Lee1 and Li-Min Huang1*

Author Affiliations

1 Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan

2 Division of Clinical Research, National Health Research Institutes, Zhunan, Taiwan

3 Department of Pediatrics, Min-Shen Hospital, Tao-Yun, Taiwan

4 Department of Pediatrics, Buddhist Tzu-Chi General Hospital, Hua-Lien, Taiwan

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BMC Infectious Diseases 2006, 6:176  doi:10.1186/1471-2334-6-176

Published: 15 December 2006



The disease burden and associated medical costs of rotavirus infections in inpatient and outpatient sectors in Taiwan were examined in anticipation of the availability of new rotavirus vaccines.


The yearly national case number and medical costs for all for inpatients and outpatients with acute gastroenteritis (AGE) were extracted from the Bureau of National Health Insurance database in Taiwan according to ICD-9-CM codes. A retrospective study was also performed using records of children with AGE seen at three hospitals in Taiwan in 2001 to identify laboratory confirmed rotavirus infection cases. The annual incidence and related medical costs of AGE due to rotavirus infection were then estimated.


Children <5 years old comprised 83.6% of inpatient and 62.0% of outpatient pediatric AGE cases in Taiwan in 2001. Rotavirus was the most common agent detected among AGE patients in this age group in the three hospitals, and was detected in 32.9% (221/672) of inpatient and 24% (23/96) of outpatient stool specimens tested for microbial etiologies. An estimated 277,400 to 624,892 cases of rotavirus infections sought medical care in Taiwan in 2001, equaling one in 2 to 5 children <5 years old required medical care due to rotavirus infection. The incidence of hospitalization due to rotavirus infections was 1,528–1,997/100,000 for children <5 years old. The total associated medical costs due to rotavirus infection were estimated at US $10–16 millions in Taiwan in 2001. Although the per-capita medical cost of rotavirus infection was lower in Taiwan than in the United States or Hong Kong, the personal economic burden was similar among the three places when normalized for gross national incomes per capita.


Infections caused by rotavirus constitute an important human and economic burden among young children in Taiwan. A safe and effective vaccine is urgently needed.