|
Characteristics of 430 patients with Staphylococcus aureus bacteremia with and without endocarditis. |
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| Bacteremia with endocarditis |
Bacteremia without endocarditis |
Total |
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| Characteristic |
(n = 74) |
(n = 356) |
(n = 430) |
OR |
95% CI |
P |
|
|
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| Age, mean years ± SD |
55 ± 22 |
59 ± 17 |
58 ± 18 |
- |
- |
0.26 |
| Male sex |
47 (64) |
221 (62) |
268 (62) |
1.06 |
0.63–1.79 |
0.82 |
| Hospital-acquired |
34 (46) |
198 (56) |
232 (54) |
0.68 |
0.41–1.12 |
0.13 |
| Previous skin disease or wound |
34 (46) |
189 (53) |
223 (52) |
0.75 |
0.45–1.24 |
0.26 |
| Previous surgerya |
18 (24) |
77 (22) |
95 (22) |
1.17 |
0.65–2.10 |
0.61 |
| Trauma in prior 2 months |
12 (16) |
98 (28) |
110 (26) |
0.51 |
0.26–0.99 |
0.04 |
| Central intravenous catheter |
10 (14) |
48 (14) |
58 (14) |
1.00 |
0.48–2.09 |
0.99 |
| Hemodialysis |
6 (8) |
38 (11) |
44 (10) |
0.74 |
0.30–1.82 |
0.51 |
| Previous S. aureus deep infection |
3 (4) |
28 (8) |
31 (7) |
0.50 |
0.15–1.67 |
0.33 |
| Previous S. aureus bacteremia |
2 (3) |
15 (4) |
17 (4) |
0.63 |
0.14–2.82 |
0.75 |
| Predisposing heart condition |
47 (64) |
63 (18) |
110 (26) |
8.10 |
4.69–13.98 |
<0.001 |
| Degenerative heart disease |
22 (30) |
32 (9) |
54 (13) |
4.28 |
2.31–7.94 |
<0.001 |
| Injection drug use |
20 (27) |
24 (7) |
44 (10) |
5.12 |
2.65–9.91 |
<0.001 |
| Prosthetic valve |
17 (23) |
1 (0.3) |
18 (4) |
105.88 |
13.82–811.08 |
<0.001 |
| Prior endocarditis |
11 (15) |
0 (0) |
11 (3) |
- |
- |
<0.001 |
| Congenital heart disease |
5 (7) |
5 (1) |
10 (2) |
5.09 |
1.43–18.05 |
0.02 |
| Mitral valve prolapse |
2 (3) |
2 (1) |
4 (1) |
4.92 |
0.68–35.48 |
0.14 |
| Rheumatic heart disease |
2 (3) |
1 (0.3) |
3 (1) |
9.86 |
0.88–110.21 |
0.08 |
| Coronary artery disease |
21 (28) |
89 (25) |
110 (26) |
1.19 |
0.68–2.08 |
0.54 |
| Corticosteroid use ≥ 1 month |
8 (11) |
37 (10) |
45 (11) |
1.05 |
0.47–2.35 |
0.92 |
| Immunosuppressive therapyb |
3 (4) |
26 (7) |
29 (7) |
0.54 |
0.16–1.82 |
0.45 |
| Diabetes |
19 (26) |
89 (25) |
108 (25) |
1.04 |
0.58–1.84 |
0.90 |
| Alcoholism |
4 (5) |
44 (12) |
48 (11) |
0.41 |
0.14–1.17 |
0.10 |
| Liver disease |
24 (32) |
43 (12) |
67 (16) |
3.49 |
1.95–6.25 |
<0.001 |
| Malignancy |
9 (12) |
54 (15) |
63 (15) |
0.77 |
0.36–1.65 |
0.51 |
| Chronic renal failure |
8 (11) |
52 (15) |
60 (14) |
0.71 |
0.32–1.56 |
0.39 |
| HIV positive |
3 (4) |
5 (1) |
8 (2) |
2.97 |
0.69–12.70 |
0.14 |
|
NOTE. Data are no. (%) of patients, unless otherwise indicated. a Includes cardiac and non-cardiac surgery during 3 months preceding the positive blood culture. b During 6 months preceding the positive blood culture. | ||||||
Ruotsalainen et al. BMC Infectious Diseases 2006 6:137 doi:10.1186/1471-2334-6-137 |
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