|
Clinical and laboratory parameters of patients diagnosed as having AIDS-associated cryptococcal meningitis between January 1999-March 2001 and from April 2001-December 2002 (before and during the fluconazole donation programme respectively) |
|||
| Before April 2001 (n = 77) |
From April 2001 (n = 128) |
P value |
|
|
|
|||
| Median age in years (range) |
33 (17–75) |
35 (21–66) |
0.4 |
| Male sex |
36 (47%) |
63 (49%) |
0.7 |
| Prior AIDS-defining illness |
20 (26%) |
26 (20%) |
0.3 |
| Prior tuberculosis |
51 (66%) |
91 (71%) |
0.5 |
| Concurrent TB treatment |
33 (43%) |
52 (41%) |
0.8 |
| CSF India Ink |
(n = 68) |
(n = 121) |
0.2 |
| Positive |
56 (82%) |
88 (73%) |
0.2 |
| CSF CLAT titer |
(n = 50) |
(n = 82) |
0.9 |
| ≥ 1000 |
36 (72%) |
57 (70%) |
0.9 |
| < 1000 |
14 (28%) |
25 (30%) |
|
| CSF fungal culture |
(n = 29) |
(n = 66) |
0.07 |
| Positive |
27 (93%) |
51 (77%) |
0.1 |
| Level of consciousness |
|||
| Stage 1 |
45 (58%) |
70 (55%) |
0.9 |
| Stage 2 |
30 (39%) |
54 (42%) |
|
| Stage 3 |
2 (3%) |
4 (3%) |
|
| Therapeutic lumbar punctures |
(n = 7) |
(n = 23) |
0.12 |
| Single |
4 |
14 |
1.0 |
| Multiple |
3 |
9 |
|
| Any treatment received |
|||
| Yes |
62 (81%) |
121 (95%) |
<0.01 |
| No |
15 (19%) |
7 (5%) |
|
| Type of initial treatment received |
(n = 62) |
(n = 121) |
|
| Fluconazole 200 |
45 (73%) |
12 (10%) |
<0.001 |
| Fluconazole 400 |
4 (6%) |
109 (90%) |
|
| Amphotericin B* |
13 (21%) |
0 (0%) |
|
|
*This was only available at the local tertiary referral hospital. Following the donation referrals for amphotericin B were no longer accepted. | |||
Schaars et al. BMC Infectious Diseases 2006 6:118 doi:10.1186/1471-2334-6-118 |
|||