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Open Access Research article

Oxidative stress in hepatitis C infected end-stage renal disease subjects

Mehmet Horoz1*, Cengiz Bolukbas2, Filiz F Bolukbas2, Mehmet Aslan1, Ahmet O Koylu1, Sahbettin Selek3 and Ozcan Erel3

Author Affiliations

1 Harran University, School of Medicine, Department of Internal Medicine, Sanliurfa, Turkey

2 Harran University, School of Medicine, Division of Gastroenterology, Sanliurfa, Turkey

3 Harran University, School of Medicine, Department of Biochemistry, Sanliurfa, Turkey

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BMC Infectious Diseases 2006, 6:114  doi:10.1186/1471-2334-6-114

Published: 14 July 2006

Abstract

Background

Both uremia and hepatitis C infection is associated with increased oxidative stress. In the present study, we aimed to find out whether hepatitis C infection has any impact on oxidative stress in hemodialysis subjects.

Methods

Sixteen hepatitis C (+) hemodialysis subjects, 24 hepatitis C negative hemodialysis subjects and 24 healthy subjects were included. Total antioxidant capacity, total peroxide level and oxidative stress index were determined in all subjects.

Results

Total antioxidant capacity was significantly higher in controls than hemodialysis subjects with or without hepatitis C infection (all p < 0.05/3), while total peroxide level and oxidative stress index were significantly lower (all p < 0.05/3). Hepatitis C (-) hemodialysis subjects had higher total antioxidant capacity compared to hepatitis C (+) hemodialysis subjects (all p < 0.05/3). Total peroxide level and oxidative stress index was comparable between hemodialysis subjects with or without hepatitis C infection (p > 0.05/3).

Conclusion

Oxidative stress is increased in both hepatitis C (+) and hepatitis C (-) hemodialysis subjects. However, hepatitis C infection seems to not cause any additional increase in oxidative stress in hemodialysis subjects and it may be partly due to protective effect of dialysis treatment on hepatitis C infection.