Table 1

Anti-LCMV activity of PAP in CBA mice

Disease Unset

Days after inoculation with LCM Virus

Survival (days)

Weight loss (grams)

Decreased mobility

Convulsions

Hair disheveled

Vehicle

Mouse #1*

<<1

NA

0

NA

NA

Mouse #2*

<<1

NA

0

NA

NA

Mouse #3*

<<1

NA

0

NA

NA

Mouse #4

6

1.5

4.5

5.5

4.5

Mouse #5

6

2

4.5

5.5

4.5

Mouse #6

7

2

5

6

5

Mouse #7

7

1.5

5

6

5

Mouse #8

7

2.5

5

6

5

Mouse #9

7

4.5

5

6

5

Mouse #10

7

4.5

5

6

5

Mouse #11

7

4.5

5

6

5

Mouse #12

8

2

6

7

6

Mouse #13

8

2.5

6

7

6

Mouse #14

8

1

6

7

6

Mouse #15

8

1.5

6

7

6

Mouse #16

8

2

6

7

6

Mouse #17

8

2

6

7

6

Mouse #18

7

1.5

5

6

5

Mouse #19

8

2

6

7

6

Mouse #20

8

1.5

6

7

6

PAP 0.25 mg/kg

Mouse #1

<<1

NA

NA

NA

NA

Mouse #2

<<1

NA

NA

NA

NA

Mouse #3

6

1

4.5

5.5

5

Mouse #4

7

1.5

5

6

5

Mouse #5

8

1.5

6

7

5.5

Mouse #6

21

0

10

NO

NO

Mouse #7

21

0

10

NO

NO

Mouse #8

21

0

10

NO

NO

Mouse #9

21

0

10

NO

NO

Mouse #10

21

0

10

NO

NO

*Mouse died after intracerebral injection; NA = not applicable, NO = not observed

Uckun et al. BMC Infectious Diseases 2005 5:9   doi:10.1186/1471-2334-5-9