Table 3

Effects of various inhibitors on S. marcescens W225 invasion of RT112 epithelial cells

Inhibitor

concentration

[%] invasion MOI 2

[%] cytotoxicity MOI 2

[%] invasion MOI 10

[%] cytotoxicity MOI 10

None

-

100

16.0 ± 2.4

100

90.0 ± 1.8

Chloroquine

200 μg/ml

98.0 ± 4.1

19.0 ± 1.8

97.2 ± 3.7

100

Cycloheximide

10 μg/ml

100

15.3 ± 2.6

102 ± 4.4

100

Cytochalasin D

5 μg/ml

54.0 ± 2.3

21.3 ± 2.6

62.0 ± 3.1

100

Dansylcadaverine

500 μM

100

18.2 ± 1.8

100

92.3 ± 5.4

Wortmannin

25 μM

55.0 ± 2.8

48.0 ± 4.4

3.0 ± 0.5

100

Colchizine

0.2 μg/ml

23.0 ± 2.1

7.2 ± 1.3

58.4 ± 6.3

46.8 ± 5.3

Paclitaxel

1 μg/ml

21.5 ± 3.2

11.7 ± 6.3

44.4 ± 5.8

40 ± 2.2

Hertle and Schwarz BMC Infectious Diseases 2004 4:16   doi:10.1186/1471-2334-4-16