Table 1

Anti-LASSA Activity of Stampidinc in CBA mice

Disease Onset (Days After Inoculation with Lassa Virus)

Decreased mobility

Scruffy Fur

Convulsions

Weight Loss (%)

Survival (days)

Group A – Vehicle

Mouse #1*

NA

NA

NA

NA

≤ 1

Mouse #2*

NA

NA

NA

NA

≤ 1

Mouse #3

6.0

6.0

7.0

4.5

8

Mouse #4

6.0

6.5

8.0

5.0

9

Mouse #5

7.5

7.0

8.0

9.0

9.5

Mouse #6

7.5

7.5

8.0

4.3

9.0

Mouse #7

7.0

7.0

8.0

4.3

9.0

Mouse #8

7.0

7.0

8.5

4.5

9.5

Mouse #9

7.0

7.0

8.5

8.3

9.5

Mouse #10

7.0

7.0

8.5

4.8

9.5

Mouse #11

8.5

8.0

9.0

5.3

10.5

Mouse #12

8.5

8.0

9.0

4.5

10.0

Mouse #13

8.0

8.5

9.5

4.5

10.0

Mouse #14

9.0

9.0

10.5

4.1

11.0

Mouse #15

9.0

9.5

11.0

4.3

11.5

Mouse #16

9.0

10.0

NO

NO

>21

Mouse #17

9.0

10.0

NO

NO

>21

Mouse #18

9.0

10.0

11.0

NO

>21

Mouse #19

9.0

10.0

NO

NO

>21

Mouse #20

9.5

10.0

NO

NO

>21

Group B – Stampidine 25 mg/kg

Mouse #1*

NA

NA

NA

NA

≤ 1

Mouse #2*

NA

NA

NA

NA

≤ 1

Mouse #3

6.0

6.0

7.5

4.3

8

Mouse #4

9.0

9.5

10.0

8.3

9.5

Mouse #5

9.5

10.0

NO

NO

>21

Mouse #6

9.5

10.0

NO

NO

>21

Mouse #7

10.0

9.5

NO

NO

>21

Mouse #8

9.0

10.0

NO

NO

>21

Mouse #9

10.0

10.0

NO

NO

>21

Mouse #10

8.5

9.5

NO

NO

>21

Group C – Stampidine 50 mg/kg

Mouse #1

13

13

NO

8.7

16

Mouse #2

9.0

NO

NO

NO

>21

Mouse #3

9.5

10.0

NO

NO

>21

Mouse #4

NO

NO

NO

NO

>21

Mouse #5

NO

NO

NO

NO

>21

Mouse #6

NO

NO

NO

NO

>21

Mouse #7

NO

NO

NO

NO

>21

Mouse #8

NO

NO

NO

NO

>21

Mouse #9

NO

NO

NO

NO

>21

Mouse #10

NO

NO

NO

NO

>21

*Mouse died after traumatic intracerebral injection; NA = not applicable; NO = not observed

Uckun et al. BMC Infectious Diseases 2004 4:1   doi:10.1186/1471-2334-4-1