Research article

vCJD risk in the Republic of Ireland

Michael S Harney^1,3 , Azra C Ghani² , CA Donnelly² , Rory McConn Walsh³ , Michael Walsh³ , Rachel Howley¹ , Francesca Brett¹ and Michael Farrell¹

¹CJD Surveillance Unit, Beaumont Hospital, Dublin, Ireland

²Department of Infectious Disease Epidemiology, Imperial College London, UK

³Department of Otolaryngology, Beaumont Hospital, Dublin, Ireland

author email corresponding author email

BMC Infectious Diseases 2003, 3:28doi:10.1186/1471-2334-3-28

Published:	26 November 2003

Abstract

Background

The Republic of Ireland has the second highest incidence of BSE worldwide. Only a single case of vCJD has been identified to date.

Methods

We estimate the total future number of clinical cases of vCJD using an established mathematical model, and based on infectivity of bovine tissue calculated from UK data and on the relative exposure to BSE contaminated meat.

Results

We estimate 1 future clinical case (95% CI 0 – 15) of vCJD in the Republic of Ireland. Irish exposure is from BSE infected indigenous beef products and from imported UK beef products. Additionally, 2.5% of the Irish population was exposed to UK beef through residing in the UK during the 'at-risk' period. The relative proportion of risk attributable to each of these three exposures individually is 2:2:1 respectively.

Conclusions

The low numbers of future vCJD cases estimated in this study is reassuring for the Irish population and for other countries with a similar level of BSE exposure.