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Open Access Case report

Severe fever with thrombocytopenia syndrome in children: a case report

Li-Yuan Wang12, Ning Cui3, Qing-Bin Lu4, Ying Wo2, Hong-Yu Wang12, Wei Liu2* and Wu-Chun Cao2*

Author Affiliations

1 Graduate School of Anhui Medical University, Hefei 230032, P. R. China

2 State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P. R. China

3 The 154 Hospital, People’s Liberation Army, Xinyang 464000, P. R. China

4 School of Public Health, Peking University, Beijing 100191, P. R. China

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BMC Infectious Diseases 2014, 14:366  doi:10.1186/1471-2334-14-366

Published: 3 July 2014



Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus (SFTSV) in China. Humans of all ages living in endemic areas have high risk of acquiring SFTS. Most clinical data so far have been from adults and no clinical study was available from children yet. The present study identified four SFTSV infected children through hospital based surveillance. A prospective observational study was performed to obtain their clinical and laboratory characteristics.

Case presentation

The patients’ age ranged from 4–15 years old and two were male. On hospitalization, fever, malaise and gastrointestinal syndromes were the most commonly presenting symptoms. Hemorrhagic symptoms or neurological manifestation was not recorded in any of the four pediatric patients. Hematological abnormalities at admission into hospital included leucopenia (4 cases), thrombocytopenia (1 case) and bicytopenia (1 case). The abnormal parameters included elevated aminotransferase (1 case), alanine transaminase (2 case), and lactate dehydrogenase (3 case). Laboratory parameters indicative of renal damage was not observed during the hospitalization. All the patients recovered well without sequelae being observed.


Compared with adults, pediatric patients with SFTSV infection seem to have less vague subjective complaints and less aggressive clinical course. Thrombocytopenia is suggested to be used less rigorously in recognizing SFTSV infection in pediatric patients, especially at early phase of disease.

Severe fever with thrombocytopenia syndrome; Bunyavirus; Children