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Open Access Highly Accessed Research article

Assessment of laboratory methods used in the diagnosis of congenital toxoplasmosis after maternal treatment with spiramycin in pregnancy

Isolina MX Rodrigues, Tatiane L Costa, Juliana B Avelar, Waldemar N Amaral, Ana M Castro and Mariza M Avelino*

BMC Infectious Diseases 2014, 14:349  doi:10.1186/1471-2334-14-349

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Previous reports on effect of prenatal treatment on diagnosis in congenital toxoplasmosis

Jorge Gomez- Marin   (2014-07-01 14:17)  Universidad del Quindio email

The interesting report of Rodrigues et al. fail to cite previous reports on this topic. We recently reported the effect of spyramicin on diagnostic assays such as IgM, PCR and avidity in congenitally infected newborns by Toxoplasma [1]. The Colombian multicentric newborn study performed in 2010 take into account this phenomena [2], that should be known by pediatricians when they want to discard congenital toxoplasmosis in newborns whose mothers received prenatal treatment.

1. Torres E, Rivera R, Cardona N, Sanchez V, Lora F, Gómez-Marín JE. Evaluation of IgG Anti-Toxoplasma Avidity and PCR in the Postnatal Diagnosis of Congenital Toxoplasmosis. Pediatr Infect Dis J. 2013; 32: 693-695

2. Gómez-Marin JE, de-la-Torre A, Angel-Muller E, et al. First Colombian multicentric newborn screening for congenital toxoplasmosis. PLoS Neglected Trop Dis, 2011; 5(5):e1195 

Competing interests

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