Open Access Highly Accessed Research article

Cost effectiveness of a pentavalent rotavirus vaccine in Oman

Salah Thabit Al Awaidy17*, Berhanu G Gebremeskel2, Idris Al Obeidani3, Said Al Baqlani4, Wisam Haddadin5 and Megan A O’Brien6

Author Affiliations

1 Office of HE of Health Affairs, Ministry of Health, Muscat, Oman

2 Rutgers School of Public Health, The State University of New Jersey, Piscataway, NJ, USA

3 Department of Communicable Disease Surveillance & Control, DGHA, Ministry of Health, Muscat, Oman

4 Central Public Health Laboratory, DGHA, Ministry of Health, Muscat, Oman

5 MSD EEMEA, Dubai, United Arab of Umirates

6 Global Health Outcomes, Merck & Co. Inc, West Point, PA, USA

7 Communicable Disease Advisor to Health Affairs, Office of Undersecretary of Health Affairs, Ministry of Health, Post Box 393, Muscat Postal Code 113, Sultanate of Oman, Oman

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BMC Infectious Diseases 2014, 14:334  doi:10.1186/1471-2334-14-334

Published: 17 June 2014



Rotavirus gastroenteritis (RGE) is the leading cause of diarrhea in young children in Oman, incurring substantial healthcare and economic burden. We propose to formally assess the potential cost effectiveness of implementing universal vaccination with a pentavalent rotavirus vaccine (RV5) on reducing the health care burden and costs associated with rotavirus gastroenteritis (RGE) in Oman


A Markov model was used to compare two birth cohorts, including children who were administered the RV5 vaccination versus those who were not, in a hypothetical group of 65,500 children followed for their first 5 years of life in Oman. The efficacy of the vaccine in reducing RGE-related hospitalizations, emergency department (ED) and office visits, and days of parental work loss for children receiving the vaccine was based on the results of the Rotavirus Efficacy and Safety Trial (REST). The outcome of interest was cost per quality-adjusted life year (QALY) gained from health care system and societal perspectives.


A universal RV5 vaccination program is projected to reduce, hospitalizations, ED visits, outpatient visits and parental work days lost due to rotavirus infections by 89%, 80%, 67% and 74%, respectively. In the absence of RV5 vaccination, RGE-related societal costs are projected to be 2,023,038 Omani Rial (OMR) (5,259,899 United States dollars [USD]), including 1,338,977 OMR (3,481,340 USD) in direct medical costs. However, with the introduction of RV5, direct medical costs are projected to be 216,646 OMR (563,280 USD). Costs per QALY saved would be 1,140 OMR (2,964 USD) from the health care payer perspective. An RV5 vaccination program would be considered cost saving, from the societal perspective.


Universal RV5 vaccination in Oman is likely to significantly reduce the health care burden and costs associated with rotavirus gastroenteritis and may be cost-effective from the payer perspective and cost saving from the societal perspective.

Rotavirus; Vaccine; Cost effectiveness; Oman; Markov model