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Factors affecting immunogenicity of BCG in infants, a study in Malawi, The Gambia and the UK

Yun-Gyoung Hur156*, Patricia Gorak-Stolinska1, Maeve K Lalor17, Hazzie Mvula2, Sian Floyd3, John Raynes1, Anne Ben-Smith12, Joseph R Fitchett1, Katie L Flanagan48, Sarah Burl49, Martin O Ota4, Amelia C Crampin23, Steven G Smith1 and Hazel M Dockrell1

Author Affiliations

1 Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine London WC1E 7HT, UK

2 Karonga Prevention Study, PO Box 46, Chilumba, Karonga District, Malawi

3 Department of Infectious Disease Epidemiology, Faculty of Epidemiology & Population Health, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK

4 Medical Research Council Unit, PO Box 273, Fajara, The Gambia

5 Department of Microbiology and Institute of Immunology and Immunological Diseases, Yonsei University College of Medicine, 134, Sinchondong, Seodaemun-gu, Seoul 120-752, South Korea

6 Current address: Yonsei University College of Medicine, Seoul, South Korea

7 Current address: Public Health England, London, UK

8 Current address: Monash University, Prahran, Victoria, Australia

9 Current address: Paediatric Infectious Diseases, Imperial College London, London, UK

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BMC Infectious Diseases 2014, 14:184  doi:10.1186/1471-2334-14-184

Published: 5 April 2014

Additional files

Additional file 1: Table S1:

The fold differences of each cytokine response to M. tb PPD between Gambian and Malawian infants, Gambian and UK infants. The cytokine responses to M. tb PPD were compared among Malawian and Gambian infants who were vaccinated at 1 week after birth, and UK infants vaccinated between 3-13 weeks of life [18]. d,f The fold differences of each cytokine response to M. tb PPD were calculated by dividing the median values of Gambian infants by Malawian infants with early vaccination and by dividing the median values of UK infants by those of Gambian infants, respectively. eP values for the median differences of each cytokine response to M. tb PPD between the two groups (Mann Whitney test).

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