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Open Access Research article

Phenotypic, immunologic, and clinical characteristics of patients with nontuberculous mycobacterial lung disease in Korea

Ae-Ra Lee1, Jinwoo Lee1, Sun-Mi Choi1, Moon-Woo Seong2, Sung A Kim1, Myoungsil Kim1, Kyung Ok Chae1, Ji Sun Lee1 and Jae-Joon Yim1*

Author Affiliations

1 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Republic of Korea

2 Department of Laboratory Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Republic of Korea

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BMC Infectious Diseases 2013, 13:558  doi:10.1186/1471-2334-13-558

Published: 25 November 2013

Abstract

Background

This study aimed to elucidate the phenotypic, immunologic, and clinical characteristics of Korean patients with nontuberculous mycobacterial (NTM) lung disease and compare them with non-NTM bronchiectasis (BE) patients.

Methods

We prospectively recruited patients between 20 and 80 years of age who had nodular BE type NTM lung disease. Phenotypic, immunologic, and clinical characteristics were evaluated through physical examination, laboratory tests, pulmonary function tests, and radiographic examinations. Questionnaires were also answered. The results of the evaluations were compared with the results of non-NTM BE patients.

Results

A total of 84 patients with NTM lung disease and 47 non-NTM BE patients participated in the study. Mycobacterium avium complex lung disease and M. abscessus lung disease were most common. Patients with NTM lung disease had lower body mass index than non-NTM BE patients. Scoliosis was observed more frequently in patients with NTM lung disease than in non-NTM BE patients.

Conclusions

Significant similarities were seen between Korean patients with NTM lung disease and patients from other countries. Differences in phenotypic and clinical characteristics between NTM lung disease and non-NTM BE patients suggest differences in the immunopathogenesis of NTM lung disease and non-NTM BE.

Trial registration information

ClinicalTrials.gov Registration number; NCT01616745

Keywords:
Bronchiectasis; Clinical characteristics; Immunopathogenesis; Nontuberculous mycobacterial lung disease; Phenotype