All-cause mortality in the cohorts of the Spanish AIDS Research Network (RIS) compared with the general population: 1997–2010
1 Red de Investigación en Sida, Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Avda. Monforte de Lemos, Madrid 5 28029, Spain
2 CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
3 Hospital Universitario Gregorio Marañón, Madrid, Spain
4 Hospital Universitario Carlos III, Madrid, Spain
5 Hospital Universitario San Cecilio, Granada, Spain
6 Hospital Universitario Virgen de la Victoria, Malaga, Spain
7 Hospital Universitario Germans Trias I Pujol, Badalona, Spain
8 Hospital Universitario Ramon y Cajal, Madrid, Spain
BMC Infectious Diseases 2013, 13:382 doi:10.1186/1471-2334-13-382Published: 20 August 2013
Combination antiretroviral therapy (cART) has produced significant changes in mortality of HIV-infected persons. Our objective was to estimate mortality rates, standardized mortality ratios and excess mortality rates of cohorts of the AIDS Research Network (RIS) (CoRIS-MD and CoRIS) compared to the general population.
We analysed data of CoRIS-MD and CoRIS cohorts from 1997 to 2010. We calculated: (i) all-cause mortality rates, (ii) standardized mortality ratio (SMR) and (iii) excess mortality rates for both cohort for 100 person-years (py) of follow-up, comparing all-cause mortality with that of the general population of similar age and gender.
Between 1997 and 2010, 8,214 HIV positive subjects were included, 2,453 (29.9%) in CoRIS-MD and 5,761 (70.1%) in CoRIS and 294 deaths were registered. All-cause mortality rate was 1.02 (95% CI 0.91-1.15) per 100 py, SMR was 6.8 (95% CI 5.9-7.9) and excess mortality rate was 0.8 (95% CI 0.7-0.9) per 100 py. Mortality was higher in patients with AIDS, hepatitis C virus (HCV) co-infection, and those from CoRIS-MD cohort (1997–2003).
Mortality among HIV-positive persons remains higher than that of the general population of similar age and sex, with significant differences depending on the history of AIDS or HCV coinfection.