Table 4

Univariate and multivariate Cox model for 28-day mortality with first-day clinical stage as fixed covariate
Covariables Univariate analysis Multivariate analysis
HR 95% CI P value HR 95% CI P value
Age (for each year of increase) 1.02 1.01 – 1.02 <0.001 1.01 1.00 – 1.02 <0.001
Sex
  Female 1 Reference 1 Reference
  Male 1.07 0.90 – 1.28 0.446 1.02 0.84 – 1.23 0.829
Site
  Community 1 Reference 1 Reference
  Hospital 1.41 1.18 – 1.69 <0.001 1.38 1.10 – 1.72 0.005
Source of infection
  Urinary 1 Reference 1 Reference
  Respiratory 2.53 1.89 – 3.39 <0.001 1.75 1.25 – 2.45 0.001
  Skin and soft tissues 1.13 0.80 – 1.59 0.483 1.30 0.91 – 1.87 0.151
  Intra-abdominal 2.20 1.57 – 3.09 <0.001 1.60 1.10 – 2.32 0.013
  Other infections 2.03 1.55 – 2.66 <0.001 1.72 1.29 – 2.30 <0.001
Comorbidities
  Without comorbidities 1 Reference 1 Reference
  With any comorbidity 1.64 1.33 – 2.03 <0.001 1.06 0.84 – 1.33 0.644
SOFA score (0 – 24, for each unit of increase) 1.20 1.18 – 1.23 <0.001 1.08 1.04 – 1.12 <0.001
APACHE II score (0 – 67, for each unit of increase) 1.11 1.09 – 1.12 <0.001 1.05 1.03 – 1.07 <0.001
Blood cultures
  Not requested 1 Reference 1 Reference
  Negative 1.22 0.99 – 1.50 0.058 1.06 0.84 – 1.32 0.623
  Gram-positive bacteria 1.51 1.07 – 2.12 0.018 1.00 0.69 – 1.45 0.980
  Gram-negative bacteria 1.55 1.16 – 2.07 0.003 1.02 0.75 – 1.40 0.894
Classification of infection (fixed at admission)
  Infection without sepsis 1 Reference 1 Reference
  Sepsis 2.08 1.40 – 3.09 <0.001 1.40 0.93 – 2.09 0.105
  Severe sepsis 3.23 2.21 – 4.73 <0.001 1.50 0.99 – 2.26 0.052
  Septic shock 7.79 5.31 – 11.42 <0.001 2.10 1.33 – 3.32 0.002

León et al.

León et al. BMC Infectious Diseases 2013 13:345   doi:10.1186/1471-2334-13-345

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