MTBs-induced IFN-g secretion is increased in the Vitamin D treatment arm after 12 weeks of anti-tuberculous therapy. Diluted whole blood cells were stimulated with M. tuberculosis sonicate (MTBs) and IFN-g measured in cell supernatants after 6 days of culture. The box and whiskers plots depict cytokine responses in the 10th to 90th percentiles with the horizontal bar indicating the median levels of each group. ‘*' Denotes values significantly different p < 0.05 between levels at 0 and 12 weeks respectively as determined by paired t test analysis.
Salahuddin et al. BMC Infectious Diseases 2013 13:22 doi:10.1186/1471-2334-13-22