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Vitamin D accelerates clinical recovery from tuberculosis: results of the SUCCINCT Study [Supplementary Cholecalciferol in recovery from tuberculosis]. A randomized, placebo-controlled, clinical trial of vitamin D supplementation in patients with pulmonary tuberculosis’

Nawal Salahuddin1*, Farheen Ali2, Zahra Hasan3, Nisar Rao4, Masooma Aqeel5 and Faisal Mahmood6

Author Affiliations

1 Consultant Department of Adult Critical Care Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

2 Section of Infectious Disease, Department of Medicine, Aga Khan University, Karachi, Pakistan

3 Department of Pathology and Microbiology, Aga Khan University, Karachi, Pakistan

4 Department of Pulmonology, Ojha Institute of Chest Diseases, Karachi, Pakistan

5 Section of Pulmonary and Critical Care Medicine, Department of Medicine, Aga Khan University, Karachi, Pakistan

6 Section of Infectious Disease, Department of Medicine, Aga Khan University, Karachi, Pakistan

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BMC Infectious Diseases 2013, 13:22  doi:10.1186/1471-2334-13-22

Published: 19 January 2013

Additional files

Additional file 1:

Figure S1. Serum 25-hydroxy Vitamin D levels in the 2 study groups over the course of the study.

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Additional file 2:

Figure S2. Sputum Smear AFB Conversion rates in the 2 study groups002E.

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Additional file 3:

Table S1. ESAT6- and MTBs-stimulated IFN-g responses in whole blood cells of TB patients. Data depicts IFN-g ♦secretion in unstimulated and antigen stimulated whole blood cells. ESAT6 early secreted and T cell activated antigen-6 kDa; MTBs, Mycobacterium tuberculosis whole sonicate antigen.

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Additional file 4:

Table S2. ESAT6-induced IFN-g responses in patients with differing severity of TB. Patients with TB were divided into groups according to their TB scores; Severity Class I (TB score 0 to 5), Class II (TB score 6 – 7) and Class III (TB score ≥ 8). The data depicts IFN-g secretion in cellular supernatant of whole blood cells either unstimulated or after stimulation with ESAT6 (early secreted and T cell activated antigen-6 kDa). Values between groups were compared using determined by Kruskal-Wallis analysis.

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Additional file 5:

Table S3. ESAT6-stimulated IFN-g responses in whole blood cells of TB patients with differing 25-hydroxyvitamin D levels. Data depicts ESAT6-induced IFN-g secretion in whole blood cells after subtraction of spontaneous secretion from unstimulated cells (was equivalent to 0 pg/mL) in each case. Values between groups were compared using determined by Kruskal-Wallis analysis whereby values p < 0.05 were considered significantly different. NS – not significant values. p < 0.05 were considered significantly different.

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