Open Access Research article

Impact of positive chest X-ray findings and blood cultures on adverse outcomes following hospitalized pneumococcal lower respiratory tract infection: a population-based cohort study

Marlene Skovgaard1*, Henrik C Schønheyder2, Thomas Benfield3, Rikke B Nielsen1, Jenny D Knudsen4, Jette Bangsborg5, Christian Østergaard4, Hans-Christian Slotved6, Helle Bossen Konradsen6, Lotte Lambertsen6 and Reimar W Thomsen1

Author Affiliations

1 Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, 8200, Denmark

2 Department of Clinical Microbiology, Aalborg University Hospital, Aalborg, 9000, Denmark

3 Department of Infectious Diseases, Copenhagen University Hospital – Hvidovre, Hvidovre, 2650, Denmark

4 Department of Clinical Microbiology, Copenhagen University Hospital – Hvidovre, Hvidovre, 2650, Denmark

5 Department of Clinical Microbiology, Copenhagen University Hospital – Herlev, Herlev, 2730, Denmark

6 Statens Serum Institut, Copenhagen S, 2300, Denmark

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BMC Infectious Diseases 2013, 13:197  doi:10.1186/1471-2334-13-197

Published: 2 May 2013

Additional files

Additional file 1:

Flowchart. A detailed chart review was done for 1,169 episodes of pneumococcal isolation from the blood and/or lower respiratory tract in patients 15 years or older. Patients were excluded if they did not comply with our predefined study criteria. Thus the final study cohort consisted of 705 hospitalized patients with pneumococcal LRTI. LRT, lower respiratory tract; LRTI, lower respiratory tract infection; CRP, C-reactive protein.

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Additional file 2:

Method of LRT-sampling according to LRTI manifestation group.

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Additional file 3:

ICD-10 discharge diagnoses according to LRTI manifestation group.

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Additional file 4:

CRP and leukocyte counts according to LRTI manifestation group, stratified by age groups.

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Additional file 5:

Outcomes according to LRTI manifestation group overall and for the four supplementary analyses.

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